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Gene Expression Data
Assay Details
Assay
Reference: J:144432 Hajihosseini MK, et al., Evidence that Fgf10 contributes to the skeletal and visceral defects of an apert syndrome mouse model. Dev Dyn. 2009 Feb;238(2):376-85
Assay type: RNA in situ
MGI Accession ID: MGI:6402525
Gene symbol: Fgfr2
Gene name: fibroblast growth factor receptor 2
Probe: Fgfr2-IIIb cDNA5
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen 3C: embryonic day 17.5; Fgf10tm1Wss/Fgf10+, Fgfr2tm2.3Dsn/Fgfr2+ (more )
Note: non-rescued sample
Structure Level Pattern Image Note
TS25: coronal suture Present Regionally restricted 3C Expression was stronger and localised to the edges of the bones as well as sutural mesenchymal cells, displaced to the sides of the fusing parietal and frontal bones.

Specimen 3E: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: coronal suture Present 3E

Specimen 4B/B': embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: alveolus epithelium Present Clusters 4B , 4B' Expressed in epithelial cells at the tips of developing alveolae.
TS25: lung mesenchyme Present Diffuse 4B , 4B'

Specimen 4E/E': embryonic day 17.5; Fgfr2tm2.3Dsn/Fgfr2+ (more )
Structure Level Pattern Image Note
TS25: alveolus epithelium Present Clusters 4E , 4E' Much reduced expression in epithelial cells at the tips of developing alveolae compared with the wild-type.
TS25: lung mesenchyme Present 4E , 4E'

Specimen 4H/H': embryonic day 17.5; Fgf10tm1Wss/Fgf10+, Fgfr2tm2.3Dsn/Fgfr2+ (more )
Structure Level Pattern Image Note
TS25: alveolus epithelium Present Clusters 4H , 4H' Expressed in epithelial cells at the tips of developing alveolae, same as in the wild-type.
TS25: lung mesenchyme Present Diffuse 4H' , 4H Same as in the wild-type.

Specimen not shown: embryonic day 17.5; Fgfr2tm2.3Dsn/Fgfr2+ (more )
Structure Level Pattern Image Note
TS25: suture Present Regionally restricted Expression was stronger in calvarial sutures compared to the wild-type.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory