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Gene Expression Data
Assay Details
Assay
Reference: J:266583 Baumgartner M, et al., Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells. Development. 2018 Aug 28;145(17):dev166322
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6400918
Gene symbol: Pax6
Gene name: paired box 6
Results
Specimen 4G mut: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Pax6; magenta - Trp53 (assay MGI:6400915).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 4G The vast majority of Trp53-upregulating cells in the mutant pallium were Pax6-immunopositive radial glial cells, a significant enrichment compared with the percentage of Pax6-immunopositive radial glial cells in the mutant pallium (93.6%).
Specimen S2B: embryonic day 13.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Pax6; magenta - Casp3 (assay MGI:6400589).
Structure Level Pattern Image Note
TS21: neocortex Present Regionally restricted S2B , S2B'' , S2B' The widespread cytoplasmic staining in Pax6+ radial glial cells was co-localized with cleaved-Casp3 staining.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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