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Gene Expression Data
Assay Details
Assay
Reference: J:166528 Zacharias AL, et al., Canonical Wnt/beta-catenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye development. Dev Dyn. 2010 Dec;239(12):3215-25
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6388682
Gene symbol: Foxc1
Gene name: forkhead box C1
Antibody: anti-Foxc1
Detection system: Biotinylated secondary antibody/[Strept]avidin
Results
Specimen 6A: embryonic day 12.5; Ctnnb1tm2Kem/Ctnnb1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Littermate control; embryo was either fl/fl or fl/+.
Structure Level Pattern Image Note
TS20: perioptic mesenchyme Present Regionally restricted 6A Expression in neural crest of periocular mesenchyme.
TS20: eye epithelium Present Regionally restricted 6A Expression in surface ectoderm of palpebral conjunctiva and palpebral epidermis of eyelid.
Specimen 6B: embryonic day 12.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: eye epithelium Present Regionally restricted 6B Expression in neural crest mesenchyme and surface ectoderm independent of Ctnn1b expression in neural crest.
TS20: perioptic mesenchyme Present Regionally restricted 6B Expression in neural crest mesenchyme and surface ectoderm independent of Ctnn1b expression in neural crest.
TS20: eye mesenchyme Weak Regionally restricted 6B Diminished expression in mesenchyme adjacent to the optic cup normally fated to become sclera.
Specimen 6C: embryonic day 14.5; Ctnnb1tm2Kem/Ctnnb1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Littermate control; embryo was either fl/fl or fl/+.
Structure Level Pattern Image Note
TS22: perioptic mesenchyme Present Regionally restricted 6C Expression in neural crest of periocular mesenchyme.
TS22: conjunctiva epithelium Present Regionally restricted 6C Expression in surface ectoderm of palpebral conjunctiva and palpebral epidermis of eyelid.
TS22: eyelid epithelium Present Regionally restricted 6C Expression in surface ectoderm of palpebral conjunctiva and palpebral epidermis of eyelid.
Specimen 6D: embryonic day 14.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: conjunctiva epithelium Present Regionally restricted 6D Expression in neural crest mesenchyme and surface ectoderm was independent of Ctnn1b expression in neural crest.
TS22: eyelid epithelium Present Regionally restricted 6D Expression in neural crest mesenchyme and surface ectoderm was independent of Ctnn1b expression in neural crest.
TS22: perioptic mesenchyme Present Regionally restricted 6D Expression in neural crest mesenchyme and surface ectoderm was independent of Ctnn1b expression in neural crest.
TS22: eye mesenchyme Weak Regionally restricted 6D Diminished expression in mesenchyme adjacent to the optic cup normally fated to become sclera.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory