About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:136711 Zhao H, et al., Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol. 2008 Jun 15;318(2):276-88
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6386990
Gene symbol: Prox1
Gene name: prospero homeobox 1
Results
Specimen 4Q: embryonic day 12.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm1Dor/Fgfr2tm1Dor, Fgfr3tm1Dor/Fgfr3tm1Dor, Tg(Cryaa-cre)10Mlr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: lens Present Uniform 4Q Uniform expression in mutant lenses at a level close to that of control lens epithelium.
Specimen 4R: embryonic day 12.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm1Dor/Fgfr2tm1Dor (more )
Structure Level Pattern Image Note
TS21: lens anterior epithelium Present 4R
TS21: posterior lens fiber Strong Regionally restricted 4R Expression significantly increased in nuclei of posterior primary lens fiber cells.
Specimen 4S: embryonic day 14.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm1Dor/Fgfr2tm1Dor, Fgfr3tm1Dor/Fgfr3tm1Dor, Tg(Cryaa-cre)10Mlr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: lens Present Regionally restricted 4S Authors report expression in posterior half of mutant lens similar to that of control lens epithelium.
Specimen 4T: embryonic day 14.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm1Dor/Fgfr2tm1Dor (more )
Structure Level Pattern Image Note
TS22: anterior lens fiber Strong Regionally restricted 4T High levels of expression in newly differentiated secondary lens fiber cells at lens equator.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory