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Gene Expression Data
Assay Details
Assay
Reference: J:272619 Aydogdu N, et al., TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme. Development. 2018 Nov 26;145(23):dev171827
Assay type: RNA in situ
MGI Accession ID: MGI:6385675
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Probe: Bmp4 probe81
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 4F control: embryonic day 14.5; Tbx2tm2.2Vmc/?, Tbx3tm3.2Moon/?, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS22: ureteral mesenchyme Present Regionally restricted 4F control Bmp4 Expression was detected in smooth muscle cell progenitors.
Specimen 4F Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl: embryonic day 14.5; Tbx2tm2.2Vmc/Tbx2tm2.2Vmc, Tbx3tm3.2Moon/Tbx3tm3.2Moon, Tbx18tm4(cre)Akis/Tbx18+, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: ureteral mesenchyme Strong 4F Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl Bmp4
Specimen S7B control: embryonic day 12.5; Tbx2tm2.2Vmc/?, Tbx3tm3.2Moon/?, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS20: ureteral mesenchyme Present Non-Uniform S7B control The highest level of expression was in cells adjacent to the epithelium.
TS20: ureteral mesenchyme subepithelial layer Present S7B control
Specimen S7B Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl: embryonic day 12.5; Tbx2tm2.2Vmc/Tbx2tm2.2Vmc, Tbx3tm3.2Moon/Tbx3tm3.2Moon, Tbx18tm4(cre)Akis/Tbx18+, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: ureteral mesenchyme Present Non-Uniform S7B Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl Expression appeared unchanged in the conditional mutant ureter.
TS20: ureteral mesenchyme subepithelial layer Present S7B Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl Expression appeared unchanged in the conditional mutant ureter.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory