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Gene Expression Data
Assay Details
Assay
Reference: J:135407 Liao J, et al., Identification of downstream genetic pathways of Tbx1 in the second heart field. Dev Biol. 2008 Apr 15;316(2):524-37
Assay type: RNA in situ
MGI Accession ID: MGI:6385050
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Probe: Isl1 probe33
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1J: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: secondary heart field Present Regionally restricted 1J Expression cranial part of second heart field (SHF).
TS13: branchial pouch endoderm Present Regionally restricted 1J
Specimen 1K: embryonic day 8.5; Tbx1tm2.2Bem/Tbx1tm2.2Bem (more )
Structure Level Pattern Image Note
TS13: secondary heart field Present Regionally restricted 1K Expression not reduced in cranial part of second heart field (SHF).
TS13: branchial pouch endoderm Present 1K No change in expression in pharyngeal pouch endoderm.
Specimen 1L: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: secondary heart field Present Regionally restricted 1L Expression in caudal part of second heart field (SHF).
TS13: branchial pouch endoderm Present 1L
Specimen 1M: embryonic day 8.5; Tbx1tm2.2Bem/Tbx1tm2.2Bem (more )
Structure Level Pattern Image Note
TS13: secondary heart field Weak Regionally restricted 1M Expression reduced in caudal part of second heart field (SHF).
TS13: branchial pouch endoderm Present 1M No change in expression in pharyngeal pouch endoderm.
Specimen 1N: embryonic day 9.0 (more )
Structure Level Pattern Image Note
TS14: secondary heart field Present Regionally restricted 1N Expression cranial and caudal parts of second heart field (SHF).
TS14: branchial pouch endoderm Present 1N
Specimen 1O: embryonic day 9.0; Tbx1tm2.2Bem/Tbx1tm2.2Bem (more )
Structure Level Pattern Image Note
TS14: secondary heart field Weak Regionally restricted 1O Expression reduced in caudal part of second heart field (SHF).
TS14: branchial pouch endoderm Present 1O No change in expression in pharyngeal pouch endoderm.
Specimen 4A: embryonic day 9.0; Tbx1tm2.1Bem/Tbx1+, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS14: secondary heart field Present 4A
Specimen 4B: embryonic day 9.0; Tbx1tm2.1Bem/Tbx1tm2.2Bem, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS14: secondary heart field Weak Regionally restricted 4B Authors report same changes in expression as in Tbx1-/- embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory