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Gene Expression Data
Assay Details
Assay
Reference: J:119274 Georgia S, et al., p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev Biol. 2006 Oct 1;298(1):22-31
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6364172
Gene symbol: Pdx1
Gene name: pancreatic and duodenal homeobox 1
Antibody: anti-Pdx1
Detection system: Secondary antibody coupled to fluorescein
Results
Specimen 1B: embryonic day 10.5 (more )
Note: Double labeled: green - Pdx1; red - p57 (Cdkn1c assay MGI:6364171).
Structure Level Pattern Image Note
TS17: pancreas primordium Present Regionally restricted 1B Expression in epithelial progenitor cells.
Specimen 1C: embryonic day 11.5 (more )
Note: Double labeled: green - Pdx1; red - p57 (Cdkn1c assay MGI:6364171).
Structure Level Pattern Image Note
TS19: pancreas primordium epithelium Present 1C Expression in epithelial progenitor cells.
Specimen 1D: embryonic day 12.5 (more )
Note: Double labeled: green - Pdx1; red - p57 (Cdkn1c assay MGI:6364171).
Structure Level Pattern Image Note
TS20: pancreas epithelium Present 1D Expression in epithelial progenitor cells.
Specimen 2A: embryonic day 11.5 (more )
Note: Double labeled: green - Pdx1; yellow - BrdU
Structure Level Pattern Image Note
TS19: pancreas primordium epithelium Present Regionally restricted 2A Expression in epithelial progenitor cells. Authors report 25% of expressing cells were in S-phase and tended to reside in peripheral layer of epithelial bud.
Specimen 2B: embryonic day 11.5; Cdkn1ctm1Sje/Cdkn1ctm1Sje (more )
Note: Double labeled: green - Pdx1; yellow - BrdU
Structure Level Pattern Image Note
TS19: pancreas primordium epithelium Strong Regionally restricted 2B Authors report an increased number of pancreatic progeniors that incorporate BrdU compared to wildtype.
Specimen 4A/C: embryonic day 9.5 (more )
Note: Double labeled: green - Pdx1; red - p57 (Cdkn1c assay MGI:6364171).
Structure Level Pattern Image Note
TS15: pancreas primordium dorsal bud Present Regionally restricted 4A , 4C Expression in epithelial cells outlining the developing dorsal pancreatic bud.
Specimen E10.5 not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: pancreas primordium Ambiguous Authors report expressing-cells were depleted by E10.5
Specimen 4D/F: embryonic day 10.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Note: Double labeled: green - Pdx1; red - p57 (Cdkn1c assay MGI:6364171).
Structure Level Pattern Image Note
TS17: pancreas primordium dorsal bud Present Regionally restricted 4F , 4D Expression in epithelial cells outlining the developing dorsal pancreatic bud.
Specimen 5A: embryonic day 11.5 (more )
Note: Double labeled: green - Pdx1; red - Gcg (assay MGI:6364174).
Structure Level Pattern Image Note
TS19: pancreas primordium Present 5A
Specimen 5B: embryonic day 11.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Note: Double labeled: green - Pdx1; red - Gcg (assay MGI:6364174).
Structure Level Pattern Image Note
TS19: pancreas primordium Weak 5B Authors report depletion of progenitor cells in pancreatic region compared to wild type.
Specimen 5C: embryonic day 11.5; Cdkn1ctm1Sje/Cdkn1ctm1Sje (more )
Note: Double labeled: green - Pdx1; red - Gcg (assay MGI:6364174).
Structure Level Pattern Image Note
TS19: pancreas primordium Present 5C No increase in progenitor cells population compared to wild type.
Specimen 5D: embryonic day 11.5; Cdkn1ctm1Sje/Cdkn1c+, Hes1tm1Fgu/Hes1tm1Fgu (more )
Note: Double labeled: green - Pdx1; red - Gcg (assay MGI:6364174).
Structure Level Pattern Image Note
TS19: pancreas primordium Strong 5D Dramatic expansion of pancreatic progenitor population. Expression in a large number of cells in pancreatic region.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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