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Gene Expression Data
Assay Details
Assay
Reference: J:258043 Wang Y, et al., N(6)-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat Neurosci. 2018 Feb;21(2):195-206
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6358385
Gene symbol: Pax6
Gene name: paired box 6
Antibody: anti-Pax6 (#PRB-278P; #30130, #901301)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 3c Mettl14f/f: embryonic day 17.5; Mettl14tm1.1Czhao/Mettl14tm1.1Czhao (more )
Structure Level Pattern Image Note
TS25: cerebral cortex ventricular zone Present Regionally restricted 3c Mettl14f/f Expression is in radial glial cells.
Specimen 3c Mettl14f/f;Nestin-cre: embryonic day 17.5; Mettl14tm1.1Czhao/Mettl14tm1.1Czhao, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: cerebral cortex ventricular zone Present Regionally restricted 3c Mettl14f/f;Nestin-cre There is a 45% decrease in the number of positive radial glial cells compared to controls.
Specimen 3c Mettl14f/+;Nestin-cre: embryonic day 17.5; Mettl14tm1.1Czhao/Mettl14+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: cerebral cortex ventricular zone Present Regionally restricted 3c Mettl14f/+;Nestin-cre Expression is in radial glial cells.
Specimen S3c Mettl14f/f: embryonic day 15.5; Mettl14tm1.1Czhao/Mettl14tm1.1Czhao (more )
Structure Level Pattern Image Note
TS23: cerebral cortex ventricular layer Present Regionally restricted S3c Mettl14f/f Expression is in radial glial cells.
Specimen S3c Mettl14f/f;Nestin-cre: embryonic day 15.5; Mettl14tm1.1Czhao/Mettl14tm1.1Czhao, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: cerebral cortex ventricular layer Present Regionally restricted S3c Mettl14f/f;Nestin-cre There is a 14% decrease in the number of positive radial glial cells compared to controls.
Specimen S3c Mettl14f/+;Nestin-cre: embryonic day 15.5; Mettl14tm1.1Czhao/Mettl14+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: cerebral cortex ventricular layer Present Regionally restricted S3c Mettl14f/+;Nestin-cre Expression is in radial glial cells.
Specimen S3e Mettl14f/f: embryonic day 13.5; Mettl14tm1.1Czhao/Mettl14tm1.1Czhao (more )
Structure Level Pattern Image Note
TS21: cerebral cortex Present S3e Mettl14f/f
Specimen S3e Mettl14f/f;Nestin-cre: embryonic day 13.5; Mettl14tm1.1Czhao/Mettl14tm1.1Czhao, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: cerebral cortex Present S3e Mettl14f/f;Nestin-cre Expression in this mutant is the same as in controls.
Specimen S3e Mettl14f/+;Nestin-cre: embryonic day 13.5; Mettl14tm1.1Czhao/Mettl14tm1.1Czhao (more )
Structure Level Pattern Image Note
TS21: cerebral cortex Present S3e Mettl14f/+;Nestin-cre
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory