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Gene Expression Data
Assay Details
Assay
Reference: J:170258 Mavromatakis YE, et al., Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity. Mech Dev. 2011 Jan-Feb;128(1-2):90-103
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6355461
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Antibody: clone 40.2D6
Results
Specimen 8I: embryonic day 12.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2+ (more )
Note: Control; genotype either Foxa fl/fl; Foxa1 +/+ or Foxa2 fl/fl; Foxa1 +/-
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 8I Expression was detected in oculomotor neurons in the ventral midbrain.
Specimen 8J: embryonic day 12.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 8J The number of oculomotor neurons was severely reduced in the ventral midbrain of the E12.5 conditional knockout.
Specimen 8K: embryonic day 12.5; Foxa1tm1Gsc/Foxa1tm1Gsc (more )
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 8K Expression of oculomotor neurons appeared normal at E12.5 in this mutant.
Specimen 8L: embryonic day 12.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 8L The number of oculomotor neurons was reduced in the double conditional knockout mutant.
Specimen 8U: embryonic day 18.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2+ (more )
Note: Control; genotype either Foxa fl/fl; Foxa1 +/+ or Foxa2 fl/fl; Foxa1 +/-
Structure Level Pattern Image Note
TS26: midbrain Present Regionally restricted 8U Expression was detected in oculomotor neurons in the ventral midbrain.
Specimen 8V: embryonic day 18.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: midbrain Present Regionally restricted 8V There was almost a complete recovery of oculomotor neurons in the conditional knockout mutants by E18.5.
Specimen 8W: embryonic day 18.5; Foxa1tm1Gsc/Foxa1tm1Gsc (more )
Structure Level Pattern Image Note
TS26: midbrain Present Regionally restricted 8W Expression of oculomotor neurons appeared normal at E18.5 in this mutant.
Specimen 8X: embryonic day 18.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: midbrain Present Regionally restricted 8X Expression of oculomotor neurons does not recover to normal in the double conditional mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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