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Gene Expression Data
Assay Details
Assay
Reference: J:86841 Elms P, et al., Zic2 is required for neural crest formation and hindbrain patterning during mouse development. Dev Biol. 2003 Dec 15;264(2):391-406
Assay type: RNA in situ
MGI Accession ID: MGI:6324687
Gene symbol: Sox10
Gene name: SRY (sex determining region Y)-box 10
Probe: IMAGE clone 4164053
Probe preparation: Antisense RNA
Results
Specimen 4A: embryonic day 9.0 (more )
Note: 13-somite stage
Structure Level Pattern Image Note
TS14: migrating neural crest Present Regionally restricted 4A
TS14: 1st branchial arch mesenchyme derived from neural crest Present 4A
TS14: 2nd branchial arch mesenchyme derived from neural crest Present 4A
TS14: facio-acoustic neural crest Present 4A
TS14: head mesenchyme derived from neural crest Present 4A
TS14: trigeminal neural crest Present 4A
Specimen 4B: embryonic day 9.0; Zic2Ku/Zic2Ku (more )
Note: 13-somite stage
Structure Level Pattern Image Note
TS14: migrating neural crest Present Regionally restricted 4B Authors report largely unaltered pattern of expression in migrating neural crest cells.
TS14: head mesenchyme derived from neural crest Present 4B Expression in few midbrain-derived crest cells within cranial mesenchyme.
TS14: 1st branchial arch mesenchyme derived from neural crest Weak 4B Fewer expressing cells in first and second branchial arches, and cranial ganglia V, VII and VIII.
TS14: 2nd branchial arch mesenchyme derived from neural crest Weak 4B Fewer expressing cells in first and second branchial arches, and cranial ganglia V, VII and VIII.
TS14: facio-acoustic neural crest Weak 4B Fewer expressing cells in first and second branchial arches, and cranial ganglia V, VII and VIII.
TS14: trigeminal neural crest Weak 4B Fewer expressing cells in first and second branchial arches, and cranial ganglia V, VII and VIII.
Specimen 4C: embryonic day 9.0 (more )
Note: 19-somite stage
Structure Level Pattern Image Note
TS14: migrating neural crest Present Regionally restricted 4C Expression rostral portion of trunk.
Specimen 4D: embryonic day 9.0; Zic2Ku/Zic2Ku (more )
Note: 19-somite stage
Structure Level Pattern Image Note
TS14: migrating neural crest Present Regionally restricted 4D Expression not markedly different from that of wild type embryos. Expression in fewer neural crest cells migrating through rostral half of somites, and in beginning of dorsal root ganglia condensations, foregut, and future sympathetic ganglia.
Specimen 4G: embryonic day 9.0 (more )
Note: 13-somite stage
Structure Level Pattern Image Note
TS14: migrating neural crest Present 4G
Specimen 4H: embryonic day 9.0; Zic2Ku/Zic2Ku (more )
Note: 13-somite stage
Structure Level Pattern Image Note
TS14: migrating neural crest Weak 4H Expression in reduced number of migrating cells.
Specimen 5A: embryonic day 9.0 (more )
Note: 18-somite stage
Structure Level Pattern Image Note
TS14: neural crest Present Regionally restricted 5A
Specimen 5B: embryonic day 9.0; Zic2Ku/Zic2Ku (more )
Note: 18-somite stage
Structure Level Pattern Image Note
TS14: neural crest Weak Regionally restricted 5B Expression in fewer cells in mutant neurectoderm.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory