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Gene Expression Data
Assay Details
Assay
Reference: J:185807 Nowotschin S, et al., Interaction of Wnt3a, Msgn1 and Tbx6 in neural versus paraxial mesoderm lineage commitment and paraxial mesoderm differentiation in the mouse embryo. Dev Biol. 2012 Jul 1;367(1):1-14
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6287752
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: Anti-Sox2 (Clone 245610) (MAB2018)
Detection system: Alexa Fluor 568
Results
Specimen 6A1/A2: embryonic day 8.5 (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: primitive streak Present 6A1/A2 Expression localized to cells within the primitive streak
Specimen 6A3/A4: embryonic day 8.5 (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: neural tube Present 6A3/A4 Expression in cells of axial (primary) neural tube.
Specimen 6B1/B2: embryonic day 8.5; Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: primitive streak Present Regionally restricted 6B1/B2 Authors report expression in single mutatnt cells of primitive streak region.
Specimen 6B3/B4: embryonic day 8.5; Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: neural tube Present Regionally restricted 6B3/B4 Expression in cells of axial (primary) neural tube. Expression also in cell clusters lateral to and which maintained attachment to the axial neural tube .
Specimen 6C1/C2: embryonic day 8.5; Msgn1tm1Wb/Msgn1tm1Wb (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: primitive streak Present Single cells 6C1/C2 Authors report expression in single mutatnt cells of primitive streak region.
Specimen 6C3/C4: embryonic day 8.5; Msgn1tm1Wb/Msgn1tm1Wb (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: neural tube Present 6C3/C4 Expression in cells of axial (primary) neural tube.
Specimen 6D1/D2: embryonic day 8.5; Tbx6tm2Pa/Tbx6tm2Pa (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: embryo Present Regionally restricted 6D1/D2 Ectopic expression in tail region.
Specimen 6D3/D4: embryonic day 8.5; Tbx6tm2Pa/Tbx6tm2Pa (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: neural tube Present Regionally restricted 6D3/D4 Expression in cells of ectopic lateral neural tubes.
Specimen 6E1/E2: embryonic day 8.5; Msgn1tm1Wb/Msgn1tm1Wb, Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: primitive streak Present 6E1/E2
Specimen 6E3/E4: embryonic day 8.5; Msgn1tm1Wb/Msgn1tm1Wb, Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: neural tube Weak Regionally restricted 6E3/E4 Expression in axial neural tube as well as in the ventral neural tube. Levels of expression were not as high compared to single mutatnt counterpart.
Specimen 6F1/F2: embryonic day 8.5; Tbx6tm2Pa/Tbx6tm2Pa, Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: primitive streak Present 6F1/F2
Specimen 6F3/F4: embryonic day 8.5; Tbx6tm2Pa/Tbx6tm2Pa, Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: neural tube Weak Regionally restricted 6F3/F4 Expression in axial neural tube as well as in the ventral neural tube. Levels of expression were not as high compared to single mutatnt counterpart.
Specimen 6G1/G2: embryonic day 8.5; Msgn1tm1Wb/Msgn1tm1Wb, Tbx6tm2Pa/Tbx6tm2Pa (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: primitive streak Present Regionally restricted 6G1/G2 Ectopic expression within primiitve streak region.
Specimen 6G3/G4: embryonic day 8.5; Msgn1tm1Wb/Msgn1tm1Wb, Tbx6tm2Pa/Tbx6tm2Pa (more )
Note: 10-12 somite stage
Structure Level Pattern Image Note
TS13: neural tube Present 6G3/G4 Expression in axial neural tube.
Specimen 7A1/A2: embryonic day 9.5 (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: tail Absent 7A1/A2
Specimen 7A3/A4: embryonic day 9.5 (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: neural tube Present 7A3/A4 Expression in cells of axial (primary) neural tube.
Specimen 7B1/B2: embryonic day 9.5; Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: tail Absent 7B1/B2
Specimen 7B3/B4: embryonic day 9.5; Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: neural tube Present Regionally restricted 7B3/B4 Expression in cells of axial (primary) neural tube. Expression also in cell clusters lateral to and which maintained attachment to the axial neural tube .
Specimen 7C1/C2: embryonic day 9.5; Msgn1tm1Wb/Msgn1tm1Wb (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: tail Absent 7C1/C2
Specimen 7C3/C4: embryonic day 9.5; Msgn1tm1Wb/Msgn1tm1Wb (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: neural tube Present Regionally restricted 7C3/C4 Expression in cells of axial (primary) neural tube. Additional sites of expression in ventral neural tube.
Specimen 7D1/D2: embryonic day 9.5; Tbx6tm2Pa/Tbx6tm2Pa (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: tail Present Regionally restricted 7D1/D2 Ectopic expression in tail region.
Specimen 7D3/D4: embryonic day 9.5; Tbx6tm2Pa/Tbx6tm2Pa (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: neural tube Present Regionally restricted 7D3/D4 Expression in cells of ectopic lateral neural tubes.
Specimen 7E1/E2: embryonic day 9.5; Msgn1tm1Wb/Msgn1tm1Wb, Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: tail Absent 7E1/E2
Specimen 7E3/E4: embryonic day 9.5; Msgn1tm1Wb/Msgn1tm1Wb, Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: neural tube Weak Regionally restricted 7E3/E4 Expression in axial neural tube as well as in the ventral neural tube. Levels of expression were not as high compared to single mutatnt counterpart.
Specimen 7F1/F2: embryonic day 9.5; Tbx6tm2Pa/Tbx6tm2Pa, Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: tail Absent 7F1/F2
Specimen 7F3/F4: embryonic day 9.5; Tbx6tm2Pa/Tbx6tm2Pa, Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: neural tube Weak Regionally restricted 7F3/F4 Expression in axial neural tube as well as in the ventral neural tube. Levels of expression were not as high compared to single mutatnt counterpart.
Specimen 7G1/G2: embryonic day 9.5; Msgn1tm1Wb/Msgn1tm1Wb, Tbx6tm2Pa/Tbx6tm2Pa (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: tail Present Widespread 7G1/G2 Expression in tail bud region encompasing almost entire cell population in tail region.
Specimen 7G3/G4: embryonic day 9.5; Msgn1tm1Wb/Msgn1tm1Wb, Tbx6tm2Pa/Tbx6tm2Pa (more )
Note: 20-25 somite stage
Structure Level Pattern Image Note
TS15: neural tube Present 7G3/G4 Expression in axial neural tube.
Specimen 8A2/A3: embryonic day 9.5; Msgn1tm1Wb/Msgn1tm1Wb, Tbx6tm2Pa/Tbx6tm2Pa (more )
Note: 20 somite stage
Structure Level Pattern Image Note
TS15: neural tube Present 8A2/A3 Expression in axial neural tube.
Specimen 8B2/B3: embryonic day 9.5; Msgn1tm1Wb/Msgn1tm1Wb, Tbx6tm2Pa/Tbx6tm2Pa (more )
Note: 20 somite stage
Structure Level Pattern Image Note
TS15: neural tube Present Regionally restricted 8B2/B3 Expression in cells of kinked axial neural tube.
Specimen 8C2/C3: embryonic day 9.5; Msgn1tm1Wb/Msgn1tm1Wb, Tbx6tm2Pa/Tbx6tm2Pa (more )
Note: 20 somite stage
Structure Level Pattern Image Note
TS15: neural tube Present Regionally restricted 8C2/C3 Expression in cells of kinked axial neural tube. Ectopic expression in cells enclosed within, or on top of, the neural tube.
Specimen 8D2/D3: embryonic day 9.5; Msgn1tm1Wb/Msgn1tm1Wb, Tbx6tm2Pa/Tbx6tm2Pa (more )
Note: 20 somite stage
Structure Level Pattern Image Note
TS15: neural tube Present Regionally restricted 8D2/C3 Ectopic expression in cells enclosed within, or on top of, the neural tube.
Specimen 8F1/F2: embryonic day 9.5; Msgn1tm1Wb/Msgn1tm1Wb, Tbx6tm2Pa/Tbx6tm2Pa (more )
Note: 20 somite stage
Structure Level Pattern Image Note
TS15: tail Weak Regionally restricted 8F1/F2 Authors report lower levels of expression in cells undergoing apoptosis.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory