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Gene Expression Data
Assay Details
Assay
Reference: J:173636 Dravis C, et al., Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues. Dev Biol. 2011 Jul 1;355(1):138-51
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6275485
Gene symbol: Efnb2
Gene name: ephrin B2
Reporter: lacZ
Direct Detection
Results
Specimen 2A rostral: embryonic day 10.5; Efnb2tm1Henk/Efnb2+ (more )
Structure Level Pattern Image Note
TS17: foregut epithelium Present Widespread 2A rostral Expression in endoderm along length of common rostral foregut
TS17: foregut mesenchyme Present 2A rostral
Specimen 2A middle: embryonic day 10.5; Efnb2tm1Henk/Efnb2+ (more )
Structure Level Pattern Image Note
TS17: foregut epithelium Present Regionally restricted 2A middle Expression foregut endoderm at site of septation.
TS17: esophagus epithelium Strong 2A middle Higher levels of expression at future esophageal pole.
TS17: esophagus mesenchyme Present Regionally restricted 2A middle Expression in mesenchyme surrounding future esophagus.
Specimen 2A caudal: embryonic day 10.5; Efnb2tm1Henk/Efnb2+ (more )
Structure Level Pattern Image Note
TS17: esophagus epithelium Present 2A caudal Expression in septated foregut with separated esophagus and trachea.
TS17: esophagus mesenchyme Present 2A caudal Expression in mesenchyme surrounding future esophagus.
Specimen 2B rostral: embryonic day 10.5; Efnb2tm1Henk/Efnb2tm2.1Henk (more )
Structure Level Pattern Image Note
TS17: foregut Present 2B rostral
Specimen 2B middle: embryonic day 10.5; Efnb2tm1Henk/Efnb2tm2.1Henk (more )
Structure Level Pattern Image Note
TS17: foregut Present 2B middle Authors state that only unseptated foregut remains.
Specimen 2B caudal: embryonic day 10.5; Efnb2tm1Henk/Efnb2tm2.1Henk (more )
Structure Level Pattern Image Note
TS17: foregut Present 2B caudal Authors describe a fistula between esophagus and emerging bronchi at caudal end of foregut.
Specimen 2C rostral: embryonic day 11.5; Efnb2tm1Henk/Efnb2+ (more )
Structure Level Pattern Image Note
TS19: esophagus epithelium Present 2C rostral Highly expressed in epithelia and mesenchyme associated with future esophageal endoderm.
TS19: esophagus mesenchyme Present 2C rostral Highly expressed in epithelia and mesenchyme associated with future esophageal endoderm.
Specimen 2C middle: embryonic day 11.5; Efnb2tm1Henk/Efnb2+ (more )
Structure Level Pattern Image Note
TS19: esophagus epithelium Present Regionally restricted 2C middle Expression in endoderm and flanking mesenchyme at point of septation.
TS19: esophagus mesenchyme Present Regionally restricted 2C middle Expression in endoderm and flanking mesenchyme at point of septation.
Specimen 2C caudal: embryonic day 11.5; Efnb2tm1Henk/Efnb2+ (more )
Structure Level Pattern Image Note
TS19: esophagus epithelium Present 2C caudal
TS19: esophagus mesenchyme Present 2C caudal
Specimen 3B E12.5: embryonic day 12.5; Efnb2tm1Henk/Efnb2+ (more )
Structure Level Pattern Image Note
TS20: palatal shelf epithelium Present Regionally restricted 3B E12.5 Expression in leading epithelia of palatal shelves before palatal shelf closure.
TS20: palatal shelf mesenchyme Present 3B E12.5
Specimen 3B E13.5: embryonic day 13.5; Efnb2tm1Henk/Efnb2+ (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Present Regionally restricted 3B E13.5 Expression in leading epithelia of palatal shelves before palatal shelf closure.
TS21: palatal shelf mesenchyme Present 3B E13.5 Expression in mesenchyme of palatal shelves before palatal shelf closure.
Specimen 3B E14.5: embryonic day 14.5; Efnb2tm1Henk/Efnb2+ (more )
Structure Level Pattern Image Note
TS22: palatal shelf epithelium Present Regionally restricted 3B E14.5 After adhesion, strongest expression in midline epithelial seam.
Specimen S2A lacZ/+: embryonic day 10.5; Efnb2tm1Henk/Efnb2+ (more )
Structure Level Pattern Image Note
TS17: foregut Present S2A lacZ/+ Expression in pre-septation foregut.
Specimen S2A lacZ/lacZ: embryonic day 10.5; Efnb2tm1Henk/Efnb2tm2.1Henk (more )
Structure Level Pattern Image Note
TS17: foregut Present S2A lacZ/lacZ Expression in pre-septation foregut.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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