Efnb2^tm2.1Henk
Targeted Allele Detail

Summary

• Symbol: Efnb2^tm2.1Henk
• Name: ephrin B2; targeted mutation 2.1, Mark Henkemeyer
• MGI ID: MGI:5085263
• Synonyms: ephrin-B2^deltaV
• Gene: Efnb2 Location: Chr8:8667434-8711242 bp, - strand Genetic Position: Chr8, 3.42 cM
• Alliance: Efnb2^tm2.1Henk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173636
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The GTC codon for valine in exon 5 was deleted and a neo cassette was inserted 27 bp downstream of the stop codon resulting in a 53 bp deletion of 3' non-coding sequence downstream of the stop codon. The neo cassette was removed by cre mediated recombination. (J:173636)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efnb2 Mutation: 28 strains or lines available

References

• Original: J:173636 Dravis C, et al., Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues. Dev Biol. 2011 Jul 1;355(1):138-51
• All: 1 reference(s)