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Gene Expression Data
Assay Details
Assay
Reference: J:150375 Cobourne MT, et al., Sonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome. Dev Biol. 2009 Jul 1;331(1):38-49
Assay type: RNA in situ
MGI Accession ID: MGI:6209778
Gene symbol: Ptch1
Gene name: patched 1
Probe: ptc probe
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 4B: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Present Widespread 4B Expression throughout palatal shelf epithelium and much of mesenchyme.
TS21: palatal shelf mesenchyme Present Widespread 4B Expression throughout palatal shelf epithelium and much of mesenchyme.
Specimen 4F: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: palatal shelf mesenchyme Weak Regionally restricted 4F Authors report a progressively reducing gradient of expression within mesenchyme on oral side of palatal shelves as they elevate above the tongue and fuse with counterparts in the midline epithelial seam (MES).
TS22: palatal shelf epithelium Absent 4F No expression in midline epithelial seam (MES).
Specimen 4J: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: palatal shelf mesenchyme Weak Regionally restricted 4J Authors report a progressively reducing gradient of expression within mesenchyme on oral side of palatal shelves as they elevate above the tongue and fuse with counterparts in the midline.
Specimen 7C: embryonic day 13.5 (more )
Note: Bud stage.
Structure Level Pattern Image Note
TS21: molar epithelium Strong 7C Strong expression in both epithelium and mesenchyme of tooth germ.
TS21: molar mesenchyme Strong 7C Strong expression in both epithelium and mesenchyme of tooth germ.
Specimen 7M: embryonic day 14.5 (more )
Note: Cap stage.
Structure Level Pattern Image Note
TS22: molar epithelium Strong 7M Strong expression in both epithelium and mesenchyme of tooth germ.
TS22: molar mesenchyme Strong 7M Strong expression in both epithelium and mesenchyme of tooth germ.
Specimen 8C: embryonic day 14.5 (more )
Note: Cap stage.
Structure Level Pattern Image Note
TS22: incisor epithelium Strong 8C Strong expression in both epithelium and mesenchyme of tooth germ.
TS22: incisor mesenchyme Strong 8C Strong expression in both epithelium and mesenchyme of tooth germ.
Specimen 8K: embryonic day 15.5 (more )
Note: Late cap stage.
Structure Level Pattern Image Note
TS23: incisor epithelium Present 8K Expression in odontogenic epitehlium and mesenchyme.
TS23: incisor mesenchyme Present 8K Expression in odontogenic epitehlium and mesenchyme.
Specimen 8S: embryonic day 16.5 (more )
Note: Early bell stage.
Structure Level Pattern Image Note
TS24: incisor mesenchyme Present 8S Continued expression in both tissue compartments.
TS24: molar epithelium Present 8S Continued expression in both tissue compartments.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory