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Gene Expression Data
Assay Details
Assay
Reference: J:240579 Howard SR, et al., IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty. EMBO Mol Med. 2016 Jun;8(6):626-42
Assay type: RNA in situ
MGI Accession ID: MGI:5903409
Gene symbol: Igsf10
Gene name: immunoglobulin superfamily, member 10
Probe: Igsf10 cDNA1
Probe preparation: Antisense RNA
Results
Specimen 4A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: nose Absent 4A No expression in the nasal region.
TS17: forebrain Absent 4A

Specimen 4B/C: embryonic day 12.5 (more )
Note: Double stained with Gnrh1 (assayMGI:5903411).
Structure Level Pattern Image Note
TS20: nasal mesenchyme Present Graded 4B Expressed in a decreasing gradient of expression from the area surrounding the vomeronasal organ toward the nasal forebrain junction.
TS20: vomeronasal organ mesenchyme Present 4B , 4C
TS20: vomeronasal organ epithelium Absent 4B
TS20: olfactory epithelium Absent 4B

Specimen 4D: embryonic day 14.5 (more )
Note: Double stained with Gnrh1 (assayMGI:5903411).
Structure Level Pattern Image Note
TS22: nasal mesenchyme Present Regionally restricted 4D Expressed along the migratory path of GnRH neurons.

Specimen 4E: embryonic day 14.5 (more )
Note: Double stained with isolectin B4.
Structure Level Pattern Image Note
TS22: nasal mesenchyme Present Regionally restricted 4E Expressed along the migratory path of GnRH neurons, negative for isolectin b4 (a marker of vasculature).

Specimen 4G/H: embryonic day 14.5 (more )
Note: Double stained with Prph (assayMGI:5903430).
Structure Level Pattern Image Note
TS22: nasal mesenchyme Present 4H , 4G Peripherin-positive cells olfactory axons were extending within the Igsf10-positive nasal mesenchyme.

Specimen 4J: embryonic day 17.5 (more )
Note: Double stained with Gnrh1 (assayMGI:5903411).
Structure Level Pattern Image Note
TS25: hypothalamus Absent 4J

Specimen not shown: embryonic day 12.5 (more )
Note: Double stained with isolectin B4.
Structure Level Pattern Image Note
TS20: nasal mesenchyme Present But negative for isolectin b4 (a marker of vasculature).

Specimen not shown: embryonic day 17.5 (more )
Note: Double stained with isolectin B4.
Structure Level Pattern Image Note
TS25: nasal mesenchyme Present But negative for isolectin b4 (a marker of vasculature).


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/31/2023
MGI 6.22
The Jackson Laboratory