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Gene Expression Data
Assay Details
Assay
Reference: J:125317 Bellenchi GC, et al., N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev. 2007 Sep 15;21(18):2347-57
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5902565
Gene symbol: Tubb3
Gene name: tubulin, beta 3 class III
Results
Specimen 3B control: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: cerebral cortex ventricular layer Present 3B control The migrating neurons in the ventricular zone were characterized by an elongated bipolar shape.
Specimen 3B n-coffl/fl,nes: embryonic day 16.0; Cfl1tm1.1Wit/Cfl1tm1.1Wit, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: cerebral cortex ventricular layer Present 3B n-coffl/fl;nes The morphology of the differentiating neurons differed from control with multiple cell protrusions.
Specimen 5D control: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: cerebral cortex ventricular layer Present Single cells 5D control The ventricular zone contained few immunopositive differentiating neurons.
Specimen 5D n-coffl/fl,nes: embryonic day 16.0; Cfl1tm1.1Wit/Cfl1tm1.1Wit, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: cerebral cortex ventricular layer Present 5D n-coffl/fl;nes The ventricular zone of the mutant was depleted of progenitors and had increased numbers of differentiated immunopositive neurons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory