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Gene Expression Data
Assay Details
Assay
Reference: J:236776 Balmus G, et al., Synthetic lethality between PAXX and XLF in mammalian development. Genes Dev. 2016 Oct 1;30(19):2152-2157
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5827984
Gene symbol: H2ax
Gene name: H2A.X variant histone
Results
Specimen 4B Paxx+/+;Xlf+/+: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cerebral cortex Present 4B Paxx+/+;Xlf+/+
Specimen 4B Paxx+/+;Xlf-/-: embryonic day 14.5; Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS22: cerebral cortex Present 4B Paxx+/+;Xlf-/-
Specimen 4B Paxx-/-;Xlf+/+: embryonic day 14.5; Paxxem1Spj/Paxxem1Spj (more )
Structure Level Pattern Image Note
TS22: cerebral cortex Present 4B Paxx-/-;Xlf+/+
Specimen 4B Paxx-/-;Xlf-/-: embryonic day 14.5; Paxxem1Spj/Paxxem1Spj, Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS22: cerebral cortex Strong 4B Paxx-/-;Xlf-/-
Specimen S7C Paxx+/+;Xlf+/+: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: neural tube Present S7C gH2AX Paxx+/+;Xlf+/+
Specimen S7C Paxx+/+;Xlf-/-: embryonic day 10.5; Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS17: neural tube Present S7C gH2AX Paxx+/+;Xlf-/-
Specimen S7C Paxx-/-;Xlf+/+: embryonic day 10.5; Paxxem1Spj/Paxxem1Spj (more )
Structure Level Pattern Image Note
TS17: neural tube Present S7C gH2AX Paxx-/-;Xlf+/+
Specimen S7C Paxx-/-;Xlf-/-: embryonic day 10.5; Paxxem1Spj/Paxxem1Spj, Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS17: neural tube Strong S7C gH2AX Paxx-/-;Xlf-/-
Specimen S7D Paxx+/+;Xlf+/+: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: spinal cord Present S7D gH2AX Paxx+/+;Xlf+/+
Specimen S7D Paxx+/+;Xlf-/-: embryonic day 14.5; Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS22: spinal cord Present S7D gH2AX Paxx+/+;Xlf-/-
Specimen S7D Paxx-/-;Xlf+/+: embryonic day 14.5; Paxxem1Spj/Paxxem1Spj (more )
Structure Level Pattern Image Note
TS22: spinal cord Present S7D gH2AX Paxx-/-;Xlf+/+
Specimen S7D left Paxx-/-;Xlf-/-: embryonic day 14.5; Paxxem1Spj/Paxxem1Spj, Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS22: spinal cord Strong S7D gH2AX left Paxx-/-;Xlf-/-
Specimen S7D right Paxx-/-;Xlf-/-: embryonic day 14.5; Paxxem1Spj/Paxxem1Spj, Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS22: spinal cord Strong S7D gH2AX right Paxx-/-;Xlf-/-
Specimen S8B lung WT: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lung Present S8A lung WT
Specimen S8B lung Paxx-/-: embryonic day 14.5; Paxxem1Spj/Paxxem1Spj (more )
Structure Level Pattern Image Note
TS22: lung Present S8A lung Paxx-/- Expression was the same as in wild-type.
Specimen S8B lung Xlf-/-: embryonic day 14.5; Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS22: lung Present S8A lung Xlf-/- Expression was the same as in wild-type.
Specimen S8B lung Paxx-/-;Xlf-/-: embryonic day 14.5; Paxxem1Spj/Paxxem1Spj, Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS22: lung Present S8A lung Paxx-/-;Xlf-/- Expression was the same as in wild-type.
Specimen S8B heart WT: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: heart Present S8A heart WT
Specimen S8B heart Paxx-/-: embryonic day 14.5; Paxxem1Spj/Paxxem1Spj (more )
Structure Level Pattern Image Note
TS22: heart Present S8A heart Paxx-/- Expression was the same as in wild-type.
Specimen S8B heart Xlf-/-: embryonic day 14.5; Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS22: heart Present S8A heart Xlf-/- Expression was the same as in wild-type.
Specimen S8B heart Paxx-/-;Xlf-/-: embryonic day 14.5; Paxxem1Spj/Paxxem1Spj, Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS22: heart Strong S8A heart Paxx-/-;Xlf-/-
Specimen S8B liver WT: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: liver Present S8A liver WT
Specimen S8B liver Paxx-/-: embryonic day 14.5; Paxxem1Spj/Paxxem1Spj (more )
Structure Level Pattern Image Note
TS22: liver Present S8A liver Paxx-/- Expression was the same as in wild-type.
Specimen S8B liver Xlf-/-: embryonic day 14.5; Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS22: liver Present S8A liver Xlf-/- Expression was the same as in wild-type.
Specimen S8B liver Paxx-/-;Xlf-/-: embryonic day 14.5; Paxxem1Spj/Paxxem1Spj, Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS22: liver Present S8A liver Paxx-/-;Xlf-/- Expression was the same as in wild-type.
Specimen S8B skin WT: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: skin Present S8A skin WT
Specimen S8B skin Paxx-/-: embryonic day 14.5; Paxxem1Spj/Paxxem1Spj (more )
Structure Level Pattern Image Note
TS22: skin Present S8A skin Paxx-/- Expression was the same as in wild-type.
Specimen S8B skin Xlf-/-: embryonic day 14.5; Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS22: skin Present S8A skin Xlf-/- Expression was the same as in wild-type.
Specimen S8B skin Paxx-/-;Xlf-/-: embryonic day 14.5; Paxxem1Spj/Paxxem1Spj, Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS22: skin Strong S8A skin Paxx-/-;Xlf-/-
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/06/2026
MGI 6.24 		The Jackson Laboratory