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Gene Expression Data
Assay Details
Assay
Reference: J:195918 Vieux-Rochas M, et al., BMP-mediated functional cooperation between Dlx5;Dlx6 and Msx1;Msx2 during mammalian limb development. PLoS One. 2013;8(1):e51700
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5810608
Gene symbol: Msx1
Gene name: msh homeobox 1
Reporter: lacZ
Direct Detection
Results
Specimen 1E: embryonic day 10.5; Msx1tm1Bero/Msx1+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud apical ectodermal ridge Present 1E
TS17: forelimb bud mesenchyme Present Regionally restricted 1E Expression in anterior and posterior mesoderm territories.
Specimen 1F: embryonic day 10.5; Msx1tm1Bero/Msx1+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud apical ectodermal ridge Present 1F
TS17: forelimb bud mesenchyme Present Regionally restricted 1F Expression in anterior and posterior mesoderm territories.
Specimen 1K: embryonic day 11.5; Msx1tm1Bero/Msx1+ (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Present 1K
TS19: forelimb bud mesenchyme Present Regionally restricted 1K Expression in larger region underneath the AER.
Specimen 1L: embryonic day 11.5; Msx1tm1Bero/Msx1+ (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Present 1L
TS19: handplate mesenchyme Present Regionally restricted 1L Expression in larger region underneath the AER.
Specimen 1S: embryonic day 10.5; Msx1tm1Bero/Msx1+ (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present 1S
TS17: hindlimb bud mesenchyme Present Regionally restricted 1S Expression in anterior and posterior mesoderm territories.
Specimen 1T: embryonic day 10.5; Msx1tm1Bero/Msx1+ (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present 1T
TS17: hindlimb bud mesenchyme Present Regionally restricted 1T Expression in anterior and posterior mesoderm territories.
Specimen 1Y: embryonic day 11.5; Msx1tm1Bero/Msx1+ (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 1Y
TS19: hindlimb bud mesenchyme Present Regionally restricted 1Y Expression in larger region underneath the AER.
Specimen 1Y': embryonic day 11.5; Msx1tm1Bero/Msx1+ (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Strong 1Y'
TS19: footplate mesenchyme Present Regionally restricted 1Y' Expression in larger region underneath the AER.
Specimen 1Z: embryonic day 11.5; Msx1tm1Bero/Msx1+ (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 1Z
TS19: footplate mesenchyme Present Regionally restricted 1Z Expression in larger region underneath the AER.
Specimen 2A: embryonic day 10.5; Msx1tm1Bero/Msx1+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud apical ectodermal ridge Present 2A
TS17: forelimb bud mesenchyme Present Regionally restricted 2A Expression in anterior and posterior mesoderm.
Specimen 2B: embryonic day 10.5; Msx1tm1Bero/Msx1+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud apical ectodermal ridge Present 2B
TS17: forelimb bud mesenchyme Present Regionally restricted 2B Expression in anterior and posterior mesoderm.
Specimen 2C: embryonic day 10.5; Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Msx1tm1Bero/Msx1+ (more )
Note: This embryo was a single homozygote for the Dl5/6 allele. However, since that allele affects two genes, the MGI database schema requires that we need to enter an allele pair per affected gene (thus resulting in the animal looking like a double homozygote).
Structure Level Pattern Image Note
TS17: forelimb bud apical ectodermal ridge Present 2C No changes in expression compared with wildtype.
TS17: forelimb bud mesenchyme Present Regionally restricted 2C No changes in expression compared with wildtype.
Specimen 2D: embryonic day 10.5; Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Msx1tm1Bero/Msx1+ (more )
Note: This embryo was a single homozygote for the Dl5/6 allele. However, since that allele affects two genes, the MGI database schema requires that we need to enter an allele pair per affected gene (thus resulting in the animal looking like a double homozygote).
Structure Level Pattern Image Note
TS17: forelimb bud apical ectodermal ridge Present 2D No changes in expression compared with wildtype.
TS17: forelimb bud mesenchyme Present Regionally restricted 2D No changes in expression compared with wildtype.
Specimen 2E: embryonic day 10.5; Msx1tm1Bero/Msx1+ (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present 2E
TS17: hindlimb bud mesenchyme Present Regionally restricted 2E Expression in anterior and posterior mesoderm.
Specimen 2F: embryonic day 10.5; Msx1tm1Bero/Msx1+ (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present 2F
TS17: forelimb bud mesenchyme Present Regionally restricted 2F Experssion in anterior and posterior mesoderm.
Specimen 2G: embryonic day 10.5; Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Msx1tm1Bero/Msx1+ (more )
Note: This embryo was a single homozygote for the Dl5/6 allele. However, since that allele affects two genes, the MGI database schema requires that we need to enter an allele pair per affected gene (thus resulting in the animal looking like a double homozygote).
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present 2G No changes in expression compared with wildtype.
TS17: hindlimb bud mesenchyme Present Regionally restricted 2G No changes in expression compared with wildtype.
Specimen 2H: embryonic day 10.5; Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Msx1tm1Bero/Msx1+ (more )
Note: This embryo was a single homozygote for the Dl5/6 allele. However, since that allele affects two genes, the MGI database schema requires that we need to enter an allele pair per affected gene (thus resulting in the animal looking like a double homozygote).
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present 2H No changes in expression compared with wildtype.
TS17: hindlimb bud mesenchyme Present Regionally restricted 2H No changes in expression compared with wildtype.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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