Nkx6-1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:154075 Weatherbee SD, et al., A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling. Hum Mol Genet. 2009 Dec 1;18(23):4565-75
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:5805395
Gene symbol:	Nkx6-1
Gene name:	NK6 homeobox 1

Antibody:

anti-Nkx6-1

Results

Specimen 5e: embryonic day 10.5 (more

)
Note: Double labeled: red - Nkx6-1; green - Dbx1 (assay MGI:5805394).

Structure	Level	Pattern	Image	Note
TS17: neural tube lateral wall	Present	Regionally restricted	5e	Expression is in V2, V3, and motor neuron progenitor cells.

Specimen 5j: embryonic day 10.5; Mks1^krc/Mks1^krc (more

)
Note: Double labeled: red - Nkx6-1; green - Dbx1 (assay MGI:5805394).

Structure	Level	Pattern	Image	Note
TS17: neural tube lateral wall	Present	Regionally restricted	5j	The dorsal boundary of expressing V2, V3, and motor neuron progenitor cells has expanded dorsally in this mutant.

Specimen 6a: embryonic day 10.5 (more

)

Structure	Level	Pattern	Image	Note
TS17: neural tube lateral wall	Present	Regionally restricted	6a	Expression is in V2, V3, and motor neuron progenitors.

Specimen 6e: embryonic day 10.5; Mks1^krc/Mks1^krc (more

)

Structure	Level	Pattern	Image	Note
TS17: neural tube lateral wall	Present	Regionally restricted	6e	Expression is in V2, V3, and motor neuron progenitors. Additional ventral progenitors are formed in this mutant.

Specimen 6i: embryonic day 10.5; Ptch1^tm1Mps/Ptch1^tm1Mps (more

)

Structure	Level	Pattern	Image	Note
TS17: neural tube lateral wall	Present	Regionally restricted	6i	There is an expansion of the expression domain in the open neural tube.

Specimen 6m: embryonic day 10.5; Mks1^krc/Mks1^krc, Ptch1^tm1Mps/Ptch1^tm1Mps (more

)

Structure	Level	Pattern	Image	Note
TS17: neural tube lateral wall	Present	Regionally restricted	6m	Expressing V3 progenitors are largely found at the ventral midline and motor neurons and other ventral progenitors are ventrally restricted in this mutant.

Specimen 6q: embryonic day 10.5; Smo^tm1Amc/Smo^tm1Amc (more

)

Structure	Level	Pattern	Image	Note
TS17: neural tube lateral wall	Absent		6q

Specimen 6u: embryonic day 10.5; Mks1^krc/Mks1^krc, Smo^tm1Amc/Smo^tm1Amc (more

)

Structure	Level	Pattern	Image	Note
TS17: neural tube lateral wall	Present	Single cells	6u	There is some expression in ventral progenitor cells.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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