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Gene Expression Data
Assay Details
Assay
Reference: J:218995 Kihara M, et al., Itm2a expression in the developing mouse first lower molar, and the subcellular localization of Itm2a in mouse dental epithelial cells. PLoS One. 2014;9(7):e103928
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5780822
Gene symbol: Itm2a
Gene name: integral membrane protein 2A
Antibody: ITM2A Polyclonal Antibody
Detection system: Secondary antibody coupled to Alexa Fluor 568
Results
Specimen 5A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: oral epithelium Absent 5A

Specimen 5B/E: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: oral epithelium Absent 5E , 5B

Specimen 5C: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: oral epithelium Absent 5C

Specimen 5D/F: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: oral epithelium Absent 5F , 5D

Specimen 6A: embryonic day 15.0 (more )
Structure Level Pattern Image Note
TS23: outer enamel epithelium Strong 6A
TS23: inner enamel epithelium Weak 6A
TS23: primary enamel knot Absent 6A
TS23: dental sac Strong 6A
TS23: dental papilla Absent 6A
TS23: blood vessel Present Regionally restricted 6A Expressed in the blood vessels in the dental papilla.

Specimen 6B/E/F: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: enamel organ Strong Regionally restricted 6B , 6F , 6E Expressed in the outer enamel epithelium (increased expression on the buccal side) and inner enamel epithelium.
TS24: dental papilla Absent 6E , 6B , 6F
TS24: blood vessel Present Regionally restricted 6E , 6B , 6F Expressed in the blood vessels in the dental papilla.

Specimen 6C: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: outer enamel epithelium Present Regionally restricted 6C Expressed on both the buccal and lingual sides.
TS25: inner enamel epithelium Present 6C
TS25: enamel organ Present Regionally restricted 6C Expression in the region near the cervical loop was weaker than that in the other regions at the presumptive cusp sites.
TS25: dental sac Present 6C
TS25: dental papilla Absent 6C
TS25: blood vessel Present Regionally restricted 6C Expressed in the blood vessels in the dental papilla.

Specimen 6D/G: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: enamel organ Present Regionally restricted 6D , 6G Expressed in the outer enamel epithelium and inner enamel epithelium. Expression in the region near the cervical loop was weaker than that in the other regions at the presumptive cusp sites.
TS26: dental sac Present 6G , 6D
TS26: dental papilla Absent 6D , 6G
TS26: blood vessel Present Regionally restricted 6G , 6D Expressed in the blood vessels in the dental papilla.

Specimen 7A: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: inner enamel epithelium Present
TS27: outer enamel epithelium Present
TS27: enamel organ Present Regionally restricted 7A Expressed in the outer enamel epithelium and inner enamel epithelium. Expression in the region near the cervical loop was weaker than that in the other regions at the presumptive cusp sites.
TS27: dental sac Present 7A
TS27: dental papilla Absent 7A
TS27: blood vessel Present Regionally restricted 7A Expressed in the blood vessels in the dental papilla.

Specimen 7B/D/E: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: enamel organ Strong Regionally restricted 7B , 7D , 7E Expressed in ameloblasts and odontoblasts. Reduced expression in the outer enamel epithelium.
TS27: dental papilla Absent 7B , 7E , 7D
TS27: blood vessel Present Regionally restricted 7D , 7B , 7E Expressed in the blood vessels in the dental papilla.

Specimen 7C: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: enamel organ Strong Regionally restricted 7C Expressed in ameloblasts and odontoblasts.
TS27: jaw bone Strong Regionally restricted 7C Expressed in the osteoblasts of the bone tissue surrounding the tooth germ.
TS27: dental papilla Absent 7C
TS27: blood vessel Present Regionally restricted 7C Expressed in the blood vessels in the dental papilla.

Specimen 8A: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: enamel organ Strong Regionally restricted 8A Expressed in ameloblasts and odontoblasts.
TS27: jaw bone Strong Regionally restricted 8A Expressed in the osteoblasts of the bone tissue surrounding the tooth germ.
TS27: dental papilla Absent 8A
TS27: blood vessel Present Regionally restricted 8A Expressed in the blood vessels in the dental papilla.

Specimen 8B: postnatal day 4 (more )
Structure Level Pattern Image Note
TS28: enamel organ Strong Regionally restricted 8B Expressed in ameloblasts and odontoblasts.
TS28: jaw bone Strong Regionally restricted 8B Expressed in the osteoblasts of the bone tissue surrounding the tooth germ.
TS28: dental papilla Absent 8B
TS28: blood vessel Present Regionally restricted 8B

Specimen 8C/D/E/F: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: enamel organ Strong Regionally restricted 8D , 8F , 8E , 8C Strong expression in the odontoblasts and ameloblasts.
TS28: Hertwig's epithelial root sheath Present 8F , 8E , 8C , 8D
TS28: jaw bone Strong Regionally restricted 8E , 8D , 8C , 8F Expressed in the osteoblasts of the bone tissue surrounding the tooth germ.
TS28: dental papilla Absent 8E , 8F , 8D , 8C
TS28: blood vessel Present Regionally restricted 8C , 8F , 8D , 8E Expressed in the blood vessels in the dental papilla.

Specimen S2A/B/C: postnatal (more )
Structure Level Pattern Image Note
TS28: liver Present S2A/B/C


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory