Lefty2 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:116645 Cota CD, et al., Mice with mutations in Mahogunin ring finger-1 (Mgrn1) exhibit abnormal patterning of the left-right axis. Dev Dyn. 2006 Dec;235(12):3438-47
Assay type:	RNA in situ
MGI Accession ID:	MGI:5553463
Gene symbol:	Lefty2
Gene name:	left-right determination factor 2

Probe:	Lefty probe
Probe preparation:	Antisense
Assay notes:	Data was shown in Table 4. Probe used recognizes both family members.

Results

Specimen +/+ 4-8: embryonic day 8.0 (more

)
Note: 4-8 somites.

Structure	Level	Pattern	Image	Note
TS12: lateral plate mesoderm	Present	Regionally restricted		Asymmetrically expressed in the left lateral plate mesenchyme.

Specimen md-nc/md-nc 4-8 variant 1: embryonic day 8.0; Mgrn1^md-nc/Mgrn1^md-nc (more

)
Note: 4-8 somites.

Structure	Level	Pattern	Image	Note
TS12: lateral plate mesoderm	Present	Regionally restricted		50% showed asymmetric expression in the left lateral plate mesenchyme. 22.2% showed bilateral expression.

Specimen md-nc/md-nc 4-8 variant 2: embryonic day 8.0; Mgrn1^md-nc/Mgrn1^md-nc (more

)
Note: 4-8 somites.

Structure	Level	Pattern	Image	Note
TS12: lateral plate mesoderm	Absent			27.8% showed absent expression.

Specimen md-2J/md-2J 4-8 variant 1: embryonic day 8.0; Mgrn1^md-2J/Mgrn1^md-2J (more

)
Note: 4-8 somites.

Structure	Level	Pattern	Image	Note
TS12: lateral plate mesoderm	Present	Regionally restricted		50% showed normal left-side expression. 5.6% showed right-side expression. 27.8% showed bilateral expression.

Specimen md-2J/md-2J 4-8 variant 2: embryonic day 8.0; Mgrn1^md-2J/Mgrn1^md-2J (more

)
Note: 4-8 somites.

Structure	Level	Pattern	Image	Note
TS12: lateral plate mesoderm	Absent			16.7% showed absent expression.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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