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Gene Expression Data
Assay Details
Assay
Reference: J:135686 Hirashima M, et al., Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos. Dev Biol. 2008 Apr 1;316(1):149-59
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5476537
Gene symbol: Lyve1
Gene name: lymphatic vessel endothelial hyaluronan receptor 1
Antibody: Anti-Lyve1 (ALY7)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Assay notes: The AMeX method was used to process the embryos.
Results
Specimen 2C: embryonic day 14.5; Ppp1r13btm1Suda/Ppp1r13b+ (more )
Note: Double labeled: green - Lyve1; red - Pecam1 (assay MGI:5476531).
Structure Level Pattern Image Note
TS22: lymphatic system Present Regionally restricted 2C Expression was detected in endothelial cells.
Specimen 3E: embryonic day 14.5 (more )
Note: Double labeled: green - Lyve1; red - Pecam1 (assay MGI:5476531).
Structure Level Pattern Image Note
TS22: lymphatic system Present Regionally restricted 3E Expression was detected in endothelial cells.
Specimen 3F: embryonic day 14.5; Ppp1r13btm1Suda/Ppp1r13btm1Suda (more )
Note: Double labeled: green - Lyve1; red - Pecam1 (assay MGI:5476531).
Structure Level Pattern Image Note
TS22: lymphatic system Present Regionally restricted 3F Expression was detected in endothelial cells. The lymphatic vessels were distended in the mutant.
Specimen 4C/E: embryonic day 14.5; Ppp1r13btm1Suda/Ppp1r13b+ (more )
Note: Double labeled: green - Lyve1; red - Pecam1 (assay MGI:5476531).
Structure Level Pattern Image Note
TS22: lymphatic system Present Regionally restricted 4C , 4E Expression was detected in endothelial cells in back skin lymphatic vessels.
Specimen 4D/F: embryonic day 14.5; Ppp1r13btm1Suda/Ppp1r13btm1Suda (more )
Note: Double labeled: green - Lyve1; red - Pecam1 (assay MGI:5476531).
Structure Level Pattern Image Note
TS22: lymphatic system Present Regionally restricted 4D , 4F The lymphatic vessels were disorganized and partly distended in the mutant.
Specimen 4I/K: embryonic day 15.5; Ppp1r13btm1Suda/Ppp1r13b+ (more )
Note: Double labeled: green - Lyve1; red - Pecam1 (assay MGI:5476531).
Structure Level Pattern Image Note
TS23: lymphatic system Present Regionally restricted 4K , 4I Expression was detected in endothelial cells in back skin lymphatic vessels.
Specimen 4J/L: embryonic day 15.5; Ppp1r13btm1Suda/Ppp1r13btm1Suda (more )
Note: Double labeled: green - Lyve1; red - Pecam1 (assay MGI:5476531).
Structure Level Pattern Image Note
TS23: lymphatic system Present Regionally restricted 4J , 4L The collecting vessels were tortuous and distended in the mutant. Isolated ball-like structures of lymphatic endothelial cells - lymphatic islands - were detected in the mutant.
Specimen S1C/E: embryonic day 16.5; Ppp1r13btm1Suda/Ppp1r13b+ (more )
Note: Double labeled: green - Lyve1; red - Pecam1 (assay MGI:5476531).
Structure Level Pattern Image Note
TS24: lymphatic system Present Regionally restricted S1C , S1E Expression was detected in endothelial cells in back skin.
Specimen S1D/F: embryonic day 16.5; Ppp1r13btm1Suda/Ppp1r13btm1Suda (more )
Note: Double labeled: green - Lyve1; red - Pecam1 (assay MGI:5476531).
Structure Level Pattern Image Note
TS24: lymphatic system Present Regionally restricted S1D , S1F The lymphatic network was defective and lymphatic islands were detected in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory