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Gene Expression Data
Assay Details
Assay
Reference: J:53540 Kim IS, et al., Regulation of chondrocyte differentiation by Cbfa1. Mech Dev. 1999 Feb;80(2):159-70
Assay type: RNA in situ
MGI Accession ID: MGI:5439354
Gene symbol: Spp1
Gene name: secreted phosphoprotein 1
Probe: Osp probe1
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen not shown: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: humerus cartilage condensation Present Regionally restricted Expression was detected in osteoblasts and hypertrophic cells of the calcified cartilage.
TS22: radius cartilage condensation Present Regionally restricted Expression was detected in osteoblasts and hypertrophic cells of the calcified cartilage.
TS22: ulna cartilage condensation Present Regionally restricted Expression was detected in osteoblasts and hypertrophic cells of the calcified cartilage.
Specimen not shown: embryonic day 14.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS22: humerus cartilage condensation Absent
TS22: radius cartilage condensation Absent
TS22: ulna cartilage condensation Absent
Specimen 7A: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: humerus Present Regionally restricted 7A Expression was detected in osteoblasts and hypertrophic cells of the calcified cartilage.
Specimen 7B: embryonic day 17.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS25: humerus Absent 7B
Specimen 7C: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: radius Present Regionally restricted 7C Expression was detected in osteoblasts and hypertrophic cells of the calcified cartilage.
TS25: ulna Present Regionally restricted 7C Expression was detected in osteoblasts and hypertrophic cells of the calcified cartilage.
Specimen 7D: embryonic day 17.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS25: radius Present Patchy 7D Expression was detected in hypertrophic calcified cells.
TS25: ulna Present Patchy 7D Expression was detected in hypertrophic calcified cells.
Specimen Table 1: embryonic day 14.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS22: humerus cartilage condensation Absent
TS22: radius cartilage condensation Absent
TS22: ulna cartilage condensation Absent
TS22: forelimb digit cartilage condensation Absent Expression was absent as in wild type.
Specimen Table 1: embryonic day 17.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS25: humerus Absent
TS25: radius Weak Expression was significantly less than wild type.
TS25: ulna Weak Expression was significantly less than wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory