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Gene Expression Data
Assay Details
Assay
Reference: J:96092 Laugwitz KL, et al., Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005 Feb 10;433(7026):647-53
Assay type: Recombinase reporter
MGI Accession ID: MGI:5316421
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Reporter: lacZ
Direct Detection
Results
Specimen Fig. 2a middle panel: postnatal month 4; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Isl1tm1(cre)Tmj/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: heart right ventricle Present Widespread 2a_middle panel Staining is observed in a high proportion of the right ventricular myocardium.
TS28: ventricle cardiac muscle Present Widespread 2a_middle panel Staining is observed in a high proportion of the right ventricular myocardium.
Specimen Fig. 2a right panel: postnatal month 4; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Isl1tm1(cre)Tmj/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cardiac muscle tissue Present Widespread 2a_right panel Staining is observed in neonatal cardiomyocytes.
Specimen Fig. 2b left panel: postnatal day 1; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Isl1tm1(cre)Tmj/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cardiac muscle tissue Present 2b_right panel , 2b_left panel Staining is observed in 30-40% of isolated cardiomyocytes which coexpress sarcomeric alpha-actinin, indicating their origin from Isl1-positive progenitors.
Specimen Fig. 3b right embryo: embryonic day 9.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Isl1tm1(cre/Esr1*)Krc/Isl1+ (more )
Note: Conditional mutant. Tamoxifen (75 ug/g body weight) was administered to pregnant mice at E7.5. Embryos were isolated at E9.5.
Structure Level Pattern Image Note
TS15: heart Present Scattered 3b right embryo inset , 3b right embryo Staining is observed only in the looping heart.
Specimen Fig. 3e left panel: postnatal day 1; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Isl1tm1(cre/Esr1*)Krc/Isl1+ (more )
Note: Conditional mutant. Tamoxifen (75 ug/g body weight) was administered to pregnant mice at E17. Pups were analyzed at P1.
Structure Level Pattern Image Note
TS27: cardiac muscle tissue Present Scattered 3e left panel Staining is observed in cells of the conus muscle after birth.
Specimen Fig. 3e middle panel: postnatal day 1; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Isl1tm1(cre/Esr1*)Krc/Isl1+ (more )
Note: Conditional mutant. Tamoxifen (75 ug/g body weight) was administered to pregnant mice at E17. Pups were analyzed at P1.
Structure Level Pattern Image Note
TS27: right atrium Present Scattered 3e middle panel Staining is observed in cells in the right atrium after birth.
Specimen Fig. 3e right panel: postnatal day 1; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Isl1tm1(cre/Esr1*)Krc/Isl1+ (more )
Note: Conditional mutant. Tamoxifen (75 ug/g body weight) was administered to pregnant mice at E17. Pups were analyzed at P1.
Structure Level Pattern Image Note
TS27: heart right ventricle Present Scattered 3e right panel Staining is observed in cells in the right ventricle after birth.
Specimen Fig. S1a: postnatal month 2; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Isl1tm1(cre/Esr1*)Krc/Isl1+ (more )
Note: Conditional mutant. Mice were treated with tamoxifen for 5 days at 8 weeks of age.
Structure Level Pattern Image Note
TS28: outflow tract Present Single cells S1a , S1a magnification of boxed area Staining is observed in a rare subset of cells in the connective tissue of the outflow tract.
Specimen Fig. S1b: postnatal month 2; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Isl1tm1(cre/Esr1*)Krc/Isl1+ (more )
Note: Conditional mutant. Mice were treated with tamoxifen for 5 days at 8 weeks of age.
Structure Level Pattern Image Note
TS28: right atrium Present Single cells S1b , S1b magnification of boxed area Staining is observed in a subset of cells in the muscle of the free wall of the right atrium.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
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