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Gene Expression Data
Assay Details
Assay
Reference: J:57677 Winnier GE, et al., Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Dev Biol. 1999 Sep 15;213(2):418-31
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5140696
Gene symbol: Foxc1
Gene name: forkhead box C1
Reporter: lacZ
Direct Detection
Results
Specimen 1A: embryonic day 10.5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS17: branchial arch Present 1A Expression is present throughout.
TS17: outflow tract Present 1A Expression is present throughout.
TS17: primitive ventricle Present 1A Expression is present throughout.
Specimen 1B: embryonic day 10.5; Foxc1tm1Blh/Foxc1tm1Blh (more )
Structure Level Pattern Image Note
TS17: branchial arch Present 1B Expression is present throughout.
TS17: outflow tract Present 1B Expression is present throughout.
TS17: primitive ventricle Present 1B Expression is present throughout.
Specimen 1C: embryonic day 10.5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS17: 3rd branchial arch mesenchyme Present 1C Expression is present throughout.
TS17: 4th branchial arch mesenchyme Present 1C Expression is present throughout.
TS17: 6th branchial arch mesenchyme Present 1C Expression is present throughout.
TS17: 3rd arch artery Present 1C Expression is present in the endothelium.
TS17: 4th arch artery Present 1C Expression is present in the endothelium.
TS17: 6th arch artery Present 1C Expression is present in the endothelium.
TS17: 3rd branchial arch ectoderm Absent 1C
TS17: 4th branchial arch ectoderm Absent 1C
TS17: 6th branchial arch ectoderm Absent 1C
Specimen 1D: embryonic day 10.5; Foxc1tm1Blh/Foxc1tm1Blh (more )
Structure Level Pattern Image Note
TS17: 3rd branchial arch mesenchyme Present 1D Expression is present throughout.
TS17: 4th branchial arch mesenchyme Present 1D Expression is present throughout.
TS17: 6th branchial arch mesenchyme Present 1D Expression is present throughout.
TS17: 3rd arch artery Present 1D Expression is present in the endothelium.
TS17: 4th arch artery Present 1D Expression is present in the endothelium.
TS17: 6th arch artery Present 1D Expression is present in the endothelium.
TS17: 3rd branchial arch ectoderm Absent 1D
TS17: 4th branchial arch ectoderm Absent 1D
TS17: 6th branchial arch ectoderm Absent 1D
Specimen 1E: embryonic day 11.5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS19: ventricle endocardial lining Present 1E Expression is present throughout the endothelial cells of the ventricles.
Specimen Not shown: embryonic day 11.5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS19: atrioventricular canal Present Regionally restricted Expression is present in the mesenchymal, but not the endothelial, cells of the endocardial cushions.
Specimen 1F: embryonic day 11.5; Foxc1tm1Blh/Foxc1tm1Blh (more )
Structure Level Pattern Image Note
TS19: outflow tract Present 1F Expression is present throughout the muscular wall.
TS19: aortico-pulmonary spiral septum Present Regionally restricted 1F Expression is present in the endocardial cushions.
Specimen 1G: postnatal newborn; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS27: pulmonary trunk Strong 1G Expression is present in the muscular wall.
TS27: pulmonary valve Strong 1G
Specimen 1H: postnatal newborn; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS27: tricuspid valve Present 1H , 1J
TS27: mitral valve Present 1H
Specimen 1I: postnatal newborn; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS27: pulmonary trunk Strong 1I
TS27: ductus arteriosus Trace 1I Expression is downregulated in the closed ductus arteriosus.
Specimen 1K: postnatal month 5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS28: aorta Present 1K Expression is present throughout.
TS28: pulmonary trunk Present 1K Expression is present throughout.
Specimen 1L: postnatal month 5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS28: aorta Present 1L Expression is present throughout.
TS28: pulmonary trunk Present 1L Expression is present throughout.
Specimen 1M: postnatal month 5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS28: heart blood vessel Present 1M Expression is present in the smooth muscle and endothelium of the coronary vessels.
Specimen Not shown: postnatal month 5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS28: endocardial tissue Present
Specimen 2B: postnatal newborn; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS27: ductus arteriosus Trace 2B Expression is downregulated in the closed ductus arteriosus.
Specimen 2C: postnatal newborn; Foxc1tm1Blh/Foxc1tm1Blh (more )
Structure Level Pattern Image Note
TS27: arterial system Present 2C
Specimen 2D: postnatal newborn; Foxc1tm1Blh/Foxc1tm1Blh (more )
Structure Level Pattern Image Note
TS27: arterial system Present 2D
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory