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Gene Expression Data
Assay Details
Assay
Reference: J:108109 Oxburgh L, et al., TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development. 2004 Sep;131(18):4593-605
Assay type: Recombinase reporter
MGI Accession ID: MGI:4948493
Gene symbol: Bmp7
Gene name: bone morphogenetic protein 7
Reporter: lacZ
Direct Detection
Results
Specimen Fig. 1B: embryonic day 11.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Bmp7tm6(cre)Rob/Bmp7+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: metanephric mesenchyme Present Patchy 1B Staining is mosaic throughout the metanephric mesenchyme.
Specimen Fig. 1C: embryonic day 12.0; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Bmp7tm6(cre)Rob/Bmp7+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: mesenchyme of metanephros Present Regionally restricted 1C Staining is observed in four to five cell layers of nephrogenic mesenchye surrounding the collecting duct trunks with some unlabeled cells surrounding the tips and the periphery of the kidney.
Specimen Fig. 1D: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Bmp7tm6(cre)Rob/Bmp7+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: mesenchyme of metanephros Present 1D Staining is observed in the nephrogenic mesenchyme.
TS21: renal cortex Present Regionally restricted 1D Staining is observed in the collecting ducts.
TS21: comma-shaped body Present 1D Staining is observed in the renal vesicles, S-shaped bodies, and comma-shaped bodies.
TS21: renal vesicle Present 1D Staining is observed in the renal vesicles, S-shaped bodies, and comma-shaped bodies.
TS21: s-shaped body Present 1D Staining is observed in the renal vesicles, S-shaped bodies, and comma-shaped bodies.
Specimen Fig. 1F: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Bmp7tm6(cre)Rob/Bmp7+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: comma-shaped body Present 1F Staining is observed in epithelial structures such as the comma-shaped body.
Specimen Fig. 1G: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Bmp7tm6(cre)Rob/Bmp7+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: renal vesicle Present 1G Staining is observed in epithelial structures such as renal vesicles.
TS21: renal cortex Present Regionally restricted 1G
Specimen Fig. 6A: embryonic day 11.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Bmp7tm6(cre)Rob/Bmp7+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: metanephric mesenchyme Present 6A Staining is observed in the ureteric bud and condensing mesenchyme.
TS19: ureteric bud Present 6A Staining is observed in the ureteric bud and condensing mesenchyme.
Specimen Fig. 6B: embryonic day 11.5; Bmp7tm6(cre)Rob/Bmp7+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Smad4tm1Rob/Smad4tm1.1Rob (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: metanephric mesenchyme Present 6B Staining is observed throughout the blastema (condensing mesenchyme.)
TS19: ureteric bud Present Regionally restricted 6B Staining is localized to mesenchymal cells immediately surrounding the ureteric bud tips.
Specimen Fig. 6C: embryonic day 12.0; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Bmp7tm6(cre)Rob/Bmp7+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: mesenchyme of metanephros Present Ubiquitous 6C Staining is observed in all cells in the nephrogenic mesenchyme.
Specimen Fig. 6D: embryonic day 12.0; Bmp7tm6(cre)Rob/Bmp7+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Smad4tm1Rob/Smad4tm1.1Rob (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: mesenchyme of metanephros Present Non-Uniform 6D Staining is observed in cells that are mixed with unlabeled cells in the nephrogenic mesenchyme.
Specimen Fig. 6E: embryonic day 12.0; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Bmp7tm6(cre)Rob/Bmp7+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: mesenchyme of metanephros Present Ubiquitous 6E Staining is observed in all cells.
TS20: primitive collecting duct Present 6E Staining is observed in nephrogenic mesenchymal cells closely associated with the collecting duct tips.
Specimen Fig. 6F: embryonic day 12.0; Bmp7tm6(cre)Rob/Bmp7+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Smad4tm1Rob/Smad4tm1.1Rob (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: mesenchyme of metanephros Present Non-Uniform 6F Staining is observed in cells in the nephrogenic mesenchyme extensively mixed with unlabeled cells.
TS20: primitive collecting duct Present 6F Staining is observed in nephrogenic mesenchymal cells (mixed with unlabeled cells of other lineages) closely associated with the collecting duct tips.
Specimen Fig. 6G: embryonic day 14.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Bmp7tm6(cre)Rob/Bmp7+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: mesenchyme of metanephros Present Widespread 6G Staining is observed in the nephrogenic mesenchyme.
TS22: renal medullary interstitium Absent 6G Stromal cells surrounding the mesenchymal condensates are unstained.
Specimen Fig. 6H: embryonic day 14.5; Bmp7tm6(cre)Rob/Bmp7+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Smad4tm1Rob/Smad4tm1.1Rob (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: mesenchyme of metanephros Present Widespread 6H Staining is observed in the limited nephrogenic mesenchyme in mutants.
TS22: renal cortex Present Patchy 6H Staining is observed in cells mixed with unlabeled cells in the cortical layer.
Specimen Fig. 6I: embryonic day 16.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Bmp7tm6(cre)Rob/Bmp7+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: mesenchyme of metanephros Present Widespread 6I Staining is observed in the nephrogenic mesenchyme.
TS24: renal medullary interstitium Absent 6I Stromal cells are clearly unlabeled.
Specimen Fig. 6J: embryonic day 16.5; Bmp7tm6(cre)Rob/Bmp7+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Smad4tm1Rob/Smad4tm1.1Rob (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: renal cortex Present Spotted 6J Staining is observed in only a few cells within the cortical layer.
TS24: mesenchyme of metanephros Present 6J
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
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