Hmgb1 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:152838 Fu H, et al., A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci. 2009 Sep 9;29(36):11399-408
Assay type:	RNA in situ
MGI Accession ID:	MGI:4839347
Gene symbol:	Hmgb1
Gene name:	high mobility group box 1

Probe:	Hmgb1 cDNA1
Probe preparation:	Antisense RNA
Assay notes:	According to the corresponding author, a probe from the Mahoney atlas (cf J:91257) was used in this assay. However, there is more than 1 probe for this gene in that set, and it was not specified which was used to generate this data.

Results

Specimen Table 1: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: spinal cord ventricular layer	Present			Expression is restricted to the germinal zone.

Specimen Table 2: postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: spinal cord	Present	Regionally restricted		The expression pattern of this gene is suggestive of a role in glial development; it is also expressed in neurons.

2A Hmgb1 ©

Specimen 2A: postnatal day 0 (more

)
Note: Double labeled: green - Hmgb1; red - Olig2 (assay MGI:4839209).

Structure	Level	Pattern	Image	Note
TS27: spinal cord	Present	Single cells	2A Hmgb1	Expression is present in oligodendrocyte-related cells.

S3_Hmgb1 WT ©

Specimen S3 - left: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: spinal cord	Present	Regionally restricted	S3_Hmgb1 WT	Expression is present in the white matter.

Specimen S3 - right: embryonic day 18.5; Olig2^tm1Rth/Olig2^tm1Rth (more

)

Structure	Level	Pattern	Image	Note
TS26: spinal cord	Present	Regionally restricted	S3_Hmgb1 Olig2-/-	Expression in the mutant is similar to that seen in wild type; it is present in the white matter.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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