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Gene Expression Data
Assay Details
Assay
Reference: J:117061 Goebbels S, et al., Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice. Genesis. 2006 Dec;44(12):611-21
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:4429426
Gene symbol: Neurod6
Gene name: neurogenic differentiation 6
Reporter: Cre
Antibody: anti-cre (Covance)
Results
Specimen 2i: embryonic day 16.5; Neurod6tm1(cre)Kan/Neurod6+ (more )
Structure Level Pattern Image Note
TS24: cortical plate Present 2i
TS24: cerebral cortex marginal layer Absent 2i No staining is observed in Cajal-Retzius cells of the marginal zone.

Specimen 2k: embryonic day 16.5; Neurod6tm1(cre)Kan/Neurod6+ (more )
Structure Level Pattern Image Note
TS24: cerebral cortex subventricular zone Present Regionally restricted 2k , 2l Staining is not observed in proliferating (BrdU +ve) cells.

Specimen not shown: embryonic day 18.0; Neurod6tm1(cre)Kan/Neurod6+ (more )
Structure Level Pattern Image Note
TS26: dentate gyrus Absent No staining is observed in the anlage of the dentate gyrus.

Specimen 4b top: postnatal day 5; Neurod6tm1(cre)Kan/Neurod6+ (more )
Structure Level Pattern Image Note
TS28: hippocampus CA3 Present 4b P5
TS28: hippocampus granule cell layer Moderate Regionally restricted 4b P5 Labeling is observed in postmitotic granule cells.

Specimen 4b middle: postnatal day 10; Neurod6tm1(cre)Kan/Neurod6+ (more )
Structure Level Pattern Image Note
TS28: hippocampus CA3 Present 4b P10

Specimen 4b bottom: postnatal day 55; Neurod6tm1(cre)Kan/Neurod6+ (more )
Structure Level Pattern Image Note
TS28: dentate gyrus hilus Strong Regionally restricted 4b P55 Labeling is high in hilar mossy cells.
TS28: hippocampus CA3 Strong Regionally restricted 4b P55 Labeling is high in CA3 pyramidal neurons.
TS28: hippocampus granule cell layer Absent 4b P55 Labeling becomes undetectable in granule cells.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory