Neurod6 Recombinase reporter Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:117061 Goebbels S, et al., Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice. Genesis. 2006 Dec;44(12):611-21
Assay type:	Recombinase reporter
MGI Accession ID:	MGI:4429157
Gene symbol:	Neurod6
Gene name:	neurogenic differentiation 6

Reporter:	lacZ
	Direct Detection

Results

2d ©

Specimen Fig. 2d: embryonic day 13.5; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: telencephalon	Strong	Regionally restricted	2d	Staining is observed in the dorsal telencephalon, and absent from the ventricular zone and entire basal telencephalon.
TS21: cortical plate	Strong	Regionally restricted	2d	Staining is observed prominently in the cortical plate of the dorsal telencephalon.
TS21: cerebral cortex ventricular layer	Absent		2d

2e ©

Specimen Fig. 2e: embryonic day 13.5; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: hindbrain	Present	Regionally restricted	2e	Staining is observed in the medullary reticular formation, cochlear nuclei, and differentiation fields of the deep cerebellar nuclei.

2f ©

Specimen Fig. 2f: embryonic day 13.5; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: medulla oblongata	Present	Regionally restricted	2f	Staining is observed in the dorsal horn outside of the ventricular zone.

3a ©

Specimen Fig. 3a: postnatal adult; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Image
TS28: hippocampus	Present	3a
TS28: dentate gyrus	Present	3a
TS28: subiculum	Present	3a

3d ©

Specimen Fig. 3d: postnatal adult; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Image	Note
TS28: cortical layer II	Strong	3d
TS28: cortical layer III	Strong	3d
TS28: cortical layer IV	Strong	3d
TS28: cortical layer V	Strong	3d
TS28: cortical layer VI	Strong	3d
TS28: hippocampus	Strong	3d
TS28: anterior olfactory nucleus	Strong	3d	Staining is observed in the dorsal and ventral anterior olfactory nuclei.
TS28: deep cerebellar nucleus	Present	3d
TS28: gigantocellular reticular nucleus	Present	3d
TS28: pontine nucleus	Present	3d
TS28: supramammillary nucleus	Present	3d
TS28: vestibular nucleus	Present	3d

3e ©

Specimen Fig. 3e: postnatal adult; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: spinal cord	Present	Regionally restricted	3e	Staining is observed in the dorsal horn of the spinal cord.

4a top ©

Specimen Fig. 4a top pane: postnatal adult; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: dentate gyrus	Present	Regionally restricted	4a top
TS28: hippocampus CA3	Present		4a top

4a middle ©

Specimen Fig. 4a middle pane: postnatal adult; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: dentate gyrus granule cell layer	Present		4a middle	Staining is observed in granule cells in the outer shell.

5aA ©

Specimen Fig. 5a A: postnatal day 20; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: neocortex	Present	Regionally restricted	5aA	Staining is observed in projection neurons, but not in oligodendrocytes.
TS28: hippocampus CA1	Present	Regionally restricted	5aA	Staining is observed in projection neurons, but not in oligodendrocytes.

5aB ©

Specimen Fig. 5a B: postnatal day 20; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: telencephalon	Present	Regionally restricted	5aB	Staining is observed in projection neurons, but not in oligodendrocytes.

5aC ©

Specimen Fig. 5a C: postnatal day 20; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: neocortex	Present	Regionally restricted	5aC	Staining is observed in projection neurons, but not in oligodendrocytes.
TS28: hippocampus CA1	Present	Regionally restricted	5aC	Staining is observed in projection neurons, but not in oligodendrocytes.

5aD ©

Specimen Fig. 5a D: postnatal day 20; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: telencephalon	Present	Regionally restricted	5aD	Staining is observed in projection neurons, but not in oligodendrocytes.

5aE ©

Specimen Fig. 5a E: postnatal day 20; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: hippocampus CA1	Present	Regionally restricted	5aE	Staining is observed in projection neurons, but not in oligodendrocytes.

5aF ©

Specimen Fig. 5a F: postnatal day 13; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: telencephalon	Present	Regionally restricted	5aF	Staining is observed in projection neurons, but not in astrocytes.

6c ©

Specimen Fig. 6c: postnatal adult; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: hippocampus	Present	Regionally restricted	6c	Staining is observed in projection neurons, but not in interneurons.
TS28: neocortex	Present	Regionally restricted	6c	Staining is observed in projection neurons, but not in interneurons.

6d ©

Specimen Fig. 6d: postnatal adult; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: hippocampus	Present	Regionally restricted	6d	Staining is observed in projection neurons, but not in interneurons.
TS28: neocortex	Present	Regionally restricted	6d	Staining is observed in projection neurons, but not in interneurons.

6e ©

Specimen Fig. 6e: postnatal adult; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: hippocampus	Present	Regionally restricted	6e	Staining is observed in projection neurons, but not in interneurons.
TS28: neocortex	Present	Regionally restricted	6e	Staining is observed in projection neurons, but not in interneurons.

6f ©

Specimen Fig. 6f: postnatal adult; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: hippocampus	Present	Regionally restricted	6f	Staining is observed in projection neurons, but not in interneurons.
TS28: neocortex	Present	Regionally restricted	6f	Staining is observed in projection neurons, but not in interneurons.

Supplemental ©

Specimen Supplemental Figure: postnatal month 1; Neurod6^tm1(cre)Kan/Neurod6⁺, Tg(CAG-cat,-lacZ)1Brn/0 (more

)
Note: Conditional mutant.

Structure	Level	Image	Note
TS28: brain	Strong	Supplemental
TS28: spinal cord	Strong	Supplemental
TS28: heart	Absent	Supplemental
TS28: liver	Absent	Supplemental
TS28: lung	Absent	Supplemental
TS28: metanephros	Absent	Supplemental
TS28: musculature	Absent	Supplemental
TS28: pancreas	Absent	Supplemental
TS28: peripheral nerve	Absent	Supplemental
TS28: spleen	Absent	Supplemental
TS28: thymus	Weak	Supplemental	Weak staining is observed in the thymus.

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