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Gene Expression Data
Assay Details
Assay
Reference: J:93194 Lindeberg J, et al., Transgenic expression of Cre recombinase from the tyrosine hydroxylase locus. Genesis. 2004 Oct;40(2):67
Assay type: Recombinase reporter
MGI Accession ID: MGI:3842397
Gene symbol: Th
Gene name: tyrosine hydroxylase
Reporter: lacZ
Direct Detection
Results
Specimen Table 1 - cBeta-lacZ: postnatal adult; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: hippocampus Present
TS28: substantia nigra Absent
TS28: ventral tegmental area Absent
TS28: locus coeruleus Absent
TS28: adrenal medulla Absent
TS28: sympathetic ganglion Absent Staining is observed in some sparse cells.
TS28: alimentary system Present Staining is observed in cells in the GI tract walls.
TS28: heart Present Staining is observed in cells in the walls of the heart.
TS28: islets of Langerhans Absent
TS28: sweat gland Present
Specimen Table 1 - R26R-lacZ: postnatal adult; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: hippocampus Absent
TS28: substantia nigra Present
TS28: ventral tegmental area Present
TS28: locus coeruleus Present
TS28: adrenal medulla Present
TS28: sympathetic ganglion Present
TS28: alimentary system Absent Staining is observed in some sparse cells.
TS28: heart Absent Staining is observed in some sparse cells in walls of the heart.
TS28: islets of Langerhans Present
TS28: sweat gland Absent
Specimen Fig. 2d: postnatal adult; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: substantia nigra Present 2d
TS28: ventral tegmental area Present 2d
Specimen Fig. 2e: postnatal adult; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: locus coeruleus Present 2e
Specimen Fig. 2f: postnatal day 30; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: adrenal medulla Present 2f
Specimen Fig. 2g: postnatal day 5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: sympathetic ganglion Present 2g
TS28: dorsal root ganglion Present 2g Staining is observed at all levels of the spinal cord.
TS28: spinal cord Present Regionally restricted 2g Staining is observed in some cells in the ventral spinal cord.
TS28: esophagus mucosa Present Scattered 2g Staining is observed in some cells.
Specimen Fig. 3a: postnatal day 5; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: trigeminal ganglion Present 3a
Specimen Fig. 3b: postnatal day 5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cochlear ganglion Present 3b
Specimen Fig. 3c: postnatal day 5; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present 3c
Specimen Fig. 3d: postnatal day 5; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: vibrissa follicle Present Regionally restricted 3d Staining is observed in cells lining the follicle.
Specimen Fig. 3e: postnatal day 5; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: alimentary system smooth muscle Present Regionally restricted 3e Staining is observed in the muscular layer from the esophagus to the rectum.
TS28: esophagus Present Regionally restricted 3e Staining is observed in the muscular layer from the esophagus to the rectum.
Specimen Fig. 3f: postnatal month 2; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 3f
Specimen Fig. 3g: postnatal day 5; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: oral region Present Regionally restricted 3g Staining is observed in the lower jaw in epithelium adjacent to the emerging teeth.
Specimen Fig. 3h: postnatal day 5; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: eyelid Present Regionally restricted 3h Staining is observed in the rim between the fused eyelids.
Specimen Fig. 3i: postnatal day 5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: taste bud Present 3i Staining is observed on the surface of the tongue probably in the taste buds.
TS28: tongue epithelium Present 3i Staining is observed on the surface of the tongue probably in the taste buds.
Specimen Fig. 3j: postnatal day 5; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: foot skin Present 3j Staining is observed in sweat glands on the foot pad.
TS28: sweat gland Present 3j Staining is observed in sweat glands on the foot pad.
Specimen Fig. 3k: postnatal month 2; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: epithelium of epididymis Present Ubiquitous 3k Staining is observed in every cell.
TS28: spermatozoon Present Regionally restricted 3k Staining is observed in developing late spermatazoa at postnatal day 22 and beyond with some exhibiting staining at 2 months. No staining is observed at postnatal day 12 or earlier.
Specimen Fig. 3l: postnatal day 12; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: ovary primordial follicle Present 3l Staining is observed from postnatal day 5 onward.
TS28: ovary primary follicle Present Regionally restricted 3l Staining is observed in oocytes at P12.
TS28: oocyte Present 3l
Specimen not shown: postnatal day 12; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: spermatozoon Absent No staining is observed at postnatal day 12 or earlier.
Specimen not shown: postnatal day 5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: hair follicle Present
TS28: epidermis basal layer Present
TS28: salivary gland Present
Specimen not shown: postnatal day 5; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: aorta Present Scattered Staining is observed in cells in the walls of the aorta.
TS28: artery Present Scattered Staining is observed in cells in the walls of main arteries.
TS28: detrusor muscle of bladder Present Staining is observed in muscular parts.
TS28: trachea smooth muscle Present Staining is observed in muscular parts.
TS28: right atrium Present Scattered Staining is observed in some cells in the atrial wall.
TS28: heart Present Scattered Staining is observed in some cells in the heart walls.
TS28: larynx Present
Specimen Fig. 4a: postnatal adult; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: main olfactory bulb Strong Regionally restricted 4a Staining is observed in dopaminergic neurons.
Specimen Fig. 4b: postnatal adult; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: midbrain Strong Regionally restricted 4b Stinaing is observed in dopaminergic neurons in the retrorubral dopaminergic field A8.
Specimen Fig. 4c: postnatal adult; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cerebral cortex Present Scattered 4c
TS28: corpus striatum Present Scattered 4c
Specimen Fig. 4d: postnatal adult; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: septofimbrial nucleus Present Regionally restricted 4d Staining is observed in a distinct collection of cells in the septofimbrial nucleus.
Specimen Fig. 4e: postnatal adult; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: thalamus Present Regionally restricted 4e Staining is observed in the lateral thalamus (outer region) with some cells scattered more medially.
Specimen Fig. 4f: postnatal adult; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: hippocampal formation Present 4f
TS28: hippocampus Present 4f Staining is observed in neurons of all areas, and is more frequent in rostral parts.
TS28: hippocampus CA3 Present Spotted 4f Staining is sparse.
Specimen Fig. 4g: postnatal adult; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: mammillary body Strong 4g
TS28: brainstem nucleus Strong Regionally restricted 4g Staining is observed in the interfascicular nucleus.
Specimen Fig. 4h: postnatal adult; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: superior colliculus Present Regionally restricted 4h Staining is observed in a distinct stripe in the superior colliculus.
Specimen Fig. 4i: postnatal adult; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: reticular tegmental nucleus Present Regionally restricted 4i Staining is observed in the pontine reticulotegmental nucleus.
Specimen Fig. 4j: postnatal adult; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: parabrachial nucleus Present Regionally restricted 4j Staining is observed in the lateral parabrachial nucleus.
TS28: laterodorsal tegmental nucleus Present 4j
Specimen Fig. 4k: postnatal adult; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: deep cerebellar nucleus Present 4k
Specimen Fig. 4l: postnatal adult; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Thtm1(cre)Te/Th+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present Scattered 4l Staining is observed in some cells.
Specimen not shown: postnatal adult; Thtm1(cre)Te/Th+, Tg(CAG-lacZ)32And/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: inferior colliculus Present Regionally restricted Staining is observed in stripes.
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12/30/2025
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