Coch In situ reporter (knock in) Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:116965 Makishima T, et al., Targeted disruption of mouse Coch provides functional evidence that DFNA9 hearing loss is not a COCH haploinsufficiency disorder. Hum Genet. 2005 Oct;118(1):29-34
Assay type:	In situ reporter (knock in)
MGI Accession ID:	MGI:3789734
Gene symbol:	Coch
Gene name:	cochlin

Reporter:	lacZ
	Direct Detection
Assay notes:	Fixative was 1% formaldehyde, 0.2% glutaraldehyde.

Results

Specimen 2A E15: embryonic day 15.0; Coch^tm1Stw/Coch^tm1Stw (more

)

Structure	Level	Pattern	Image	Note
TS23: inner ear	Present		2A E15
TS23: inner ear vestibular component	Strong		2A E15

Specimen 2A P0: postnatal day 0; Coch^tm1Stw/Coch^tm1Stw (more

)

Structure	Level	Pattern	Image	Note
TS27: inner ear	Present		2A P0
TS27: inner ear vestibular component	Strong		2A P0

Specimen 2A P5: postnatal day 5; Coch^tm1Stw/Coch^tm1Stw (more

)

Structure	Level	Pattern	Image	Note
TS28: inner ear	Present		2A P5
TS28: inner ear vestibular component	Strong		2A P5

Specimen 2A P10: postnatal day 10; Coch^tm1Stw/Coch^tm1Stw (more

)

Structure	Level	Pattern	Image	Note
TS28: inner ear	Weak		2A P10
TS28: cochlea	Strong		2A P10

Specimen 2A P15: postnatal day 15; Coch^tm1Stw/Coch^tm1Stw (more

)

Structure	Level	Pattern	Image	Note
TS28: inner ear	Weak		2A P15
TS28: cochlea	Strong		2A P15

Specimen 2A P20: postnatal day 20; Coch^tm1Stw/Coch^tm1Stw (more

)

Structure	Level	Pattern	Image	Note
TS28: inner ear	Weak		2A P20
TS28: cochlea	Strong		2A P20

Specimen 2A P30: postnatal day 30; Coch^tm1Stw/Coch^tm1Stw (more

)

Structure	Level	Pattern	Image	Note
TS28: inner ear	Weak		2A P30
TS28: cochlea	Strong		2A P30

Specimen 2B P0: postnatal day 0; Coch^tm1Stw/Coch^tm1Stw (more

)

Structure	Level	Pattern	Image	Note
TS27: middle ear	Present	Regionally restricted	2B P0	Expression is in the tympanic membrane and absent anywhere else in the middle ear.
TS27: outer ear	Absent		2B P0

Specimen 2B P5: postnatal day 5; Coch^tm1Stw/Coch^tm1Stw (more

)

Structure	Level	Pattern	Image	Note
TS28: middle ear	Present	Regionally restricted	2B P5	Expression is in the tympanic membrane and absent anywhere else in the middle ear.
TS28: outer ear	Absent		2B P5

Specimen 2C: postnatal; Coch^tm1Stw/Coch^tm1Stw (more

)

Structure	Level	Pattern	Image	Note
TS28: spiral ligament	Present		2C
TS28: spiral limbus	Present		2C
TS28: cochlear duct	Present	Regionally restricted	2C	Expression is in cells lining the scala vestibuli.

Specimen 2D cochlear duct: postnatal; Coch^tm1Stw/Coch^tm1Stw (more

)

Structure	Level	Pattern	Image	Note
TS28: spiral ligament	Present		2D cochlear duct
TS28: spiral limbus	Present		2D cochlear duct
TS28: cochlear duct	Present	Regionally restricted	2D cochlear duct	Expression is in cells lining the scala vestibuli.

Specimen 2D ampulla: postnatal; Coch^tm1Stw/Coch^tm1Stw (more

)

Structure	Level	Pattern	Image	Note
TS28: crista ampullaris	Absent		2D ampulla

Specimen Not shown: postnatal; Coch^tm1Stw/Coch^tm1Stw (more

)

Structure	Level	Pattern	Note
TS28: saccule epithelium	Present	Regionally restricted	Expression is in the nonsensory epithelial cells and not in the sensory epithelial hair cells.
TS28: semicircular duct	Present	Regionally restricted	Expression is in the nonsensory epithelial cells and not in the sensory epithelial hair cells.
TS28: utricle epithelium	Present	Regionally restricted	Expression is in the nonsensory epithelial cells and not in the sensory epithelial hair cells.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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