Coch^tm1Stw
Targeted Allele Detail

Summary

• Symbol: Coch^tm1Stw
• Name: cochlin; targeted mutation 1, Colin L Stewart
• MGI ID: MGI:3624559
• Synonyms: Coch-LacZ
• Gene: Coch Location: Chr12:51640156-51652558 bp, + strand Genetic Position: Chr12, 22.11 cM
• Alliance: Coch^tm1Stw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105566
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was used to insert a loxP site into intron 6, an IRES-lacZ and floxed neo cassette into exon 12. Beta-gal expression was demonstrated in uterine luminal epithelium. (J:105566)

Expression

In Mice Carrying this Mutation:

29 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Coch Mutation: 42 strains or lines available

References

• Original: J:105566 Rodriguez CI, et al., Cochlin, a secreted von Willebrand factor type a domain-containing factor, is regulated by leukemia inhibitory factor in the uterus at the time of embryo implantation. Endocrinology. 2004 Mar;145(3):1410-8
• All: 1 reference(s)