Gene Expression Data
Assay Details
|
Assay
|
|
Reference:
|
J:47920
Dattani MT, et al., Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nat Genet. 1998 Jun;19(2):125-33
|
|
Assay type:
|
RNA in situ
|
|
MGI Accession ID:
|
MGI:3711942
|
|
Gene symbol:
|
Shh
|
|
Gene name:
|
sonic hedgehog
|
|
|
Results
|
Specimen
3i:
(close  )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Hesx1tm1Icar/Hesx1tm1Icar
|
|
Age:
|
embryonic day 11.5
|
|
Age Note:
|
Age of embryo at noon of plug day not specified in reference.
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Note:
|
This is a class II mutant.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS19: telencephalon |
Present |
Regionally restricted |
3i
|
As in wild-type, expression is present in the medial aspects of the medial ganglionic eminence abutting the floor of the telencephalon.
|
| TS19: diencephalon |
Present |
Regionally restricted |
3i
|
As in wild-type, expression is present in the zona limitans intrathalamica and in two parallel stripes of expression in the ventral diencephalon converging in the preoptic area.
|
Specimen
3j:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Hesx1tm1Icar/Hesx1tm1Icar
|
|
Age:
|
embryonic day 11.5
|
|
Age Note:
|
Age of embryo at noon of plug day not specified in reference.
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Note:
|
This is a class I mutant.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS19: forebrain |
Present |
|
3j
|
Expression is reduced in the mutant due to a foreshortening of the forebrain.
|
| TS19: telencephalon |
Absent |
|
3j
|
Due to the absence of the telencephalon, there is no expression where the medial ganglionic eminence should be.
|
| TS19: diencephalon |
Present |
Regionally restricted |
3j
|
Expression is present in the zona limitans intrathalamica.
|
Specimen
3k:
embryonic day 11.5
(more  )
Specimen
3k:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 11.5
|
|
Age Note:
|
Age of embryo at noon of plug day not specified in reference.
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS19: telencephalon |
Present |
Regionally restricted |
3k
|
Expression is present in the medial aspects of the medial ganglionic eminence abutting the floor of the telencephalon.
|
| TS19: diencephalon |
Present |
Regionally restricted |
3k
|
Expression is present in the zona limitans intrathalamica and in two parallel stripes of expression in the ventral diencephalon converging in the preoptic area.
|
|
Analysis Tools
