Gene Expression Data
Assay Details
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Assay
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Reference:
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J:82351
Bondjers C, et al., Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells. Am J Pathol. 2003 Mar;162(3):721-9
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Assay type:
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RNA in situ
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MGI Accession ID:
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MGI:3581539
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Gene symbol:
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Pdgfrb
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Gene name:
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platelet derived growth factor receptor, beta polypeptide
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Probe:
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PDGF-RB cDNA
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Probe preparation:
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Antisense labelled with digoxigenin RNA
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Visualized with:
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Alkaline phosphatase
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Results
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Specimen
2B:
embryonic day 14.5
(more  )
Specimen
2B:
(close  )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: blood vessel |
Present |
Regionally restricted |
2B
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In the brain, expression is present in the pericytes surrounding the capillaries.
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Specimen
2E:
embryonic day 14.5
(more )
Specimen
2E:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: arterial system |
Present |
Regionally restricted |
2E
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Expression is present in the vascular smooth muscle cells around some of the larger arteries.
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| TS22: venous system |
Absent |
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2E
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There is no, or limited, expression in the veins.
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Specimen
2H:
embryonic day 14.5
(more )
Specimen
2H:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: renal cortex |
Present |
Regionally restricted |
2H
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Expression is present in the mesangial cells in the kidney.
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Specimen
2K:
embryonic day 14.5
(more )
Specimen
2K:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: lung mesenchyme |
Present |
Regionally restricted |
2K
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Expression is found scattered in the mesenchyme in areas corresponding to ongoing angiogenesis and in the vascular smooth muscle cells surrounding developing lung arterial branches.
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Specimen
2N:
embryonic day 14.5
(more )
Specimen
2N:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: gut |
Present |
Regionally restricted |
2N
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Expression is present in the mesenchymal cells immediately subjacent to the epithelium, where angiogenesis is known to be active.
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Specimen
3C:
embryonic day 14.5; Pdgfbtm1Cbet/Pdgfb +
(more )
Specimen
3C:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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Pdgfbtm1Cbet/Pdgfb+
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: brain |
Present |
Regionally restricted |
3C
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Expression is present in the pericytes located in the capillary walls in the brain.
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Specimen
3D:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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Pdgfbtm1Cbet/Pdgfbtm1Cbet
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: brain |
Present |
Regionally restricted |
3D
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Expression is present in the pericytes located in the capillary walls in the brain; there are fewer of these cells in the mutant compared to wild type.
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Analysis Tools