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Gene Expression Data
Assay Details
Assay
Reference: J:83255 Chi CL, et al., The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum. Development. 2003 Jun;130(12):2633-44
Assay type: RNA in situ
MGI Accession ID: MGI:2677301
Gene symbol: Wnt1
Gene name: wingless-type MMTV integration site family, member 1
Probe: Wnt1 probe12
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 5A: embryonic day 8.5 (more )
Note: 8 somites. Littermate control; exact genotype not specified.
Structure Level Pattern Image Note
TS13: future midbrain Present Regionally restricted 5A Expression in a band at the caudal end of the prospective midbrain.
TS13: future midbrain neural fold Present Regionally restricted 5A Expression is present along the lateral edges of the open neural tube.
Specimen 5B: embryonic day 8.5; Fgf8tm1.3Mrt/Fgf8tm1.4Mrt, En1tm2(cre)Wrst/En1+ (more )
Note: Conditional mutant. 8 somites.
Structure Level Pattern Image Note
TS13: future midbrain neural fold Present Regionally restricted 5B Expression is present at normal levels along the lateral edges of the open neural tube, but it is not present in a band at the caudal end of the prospective midbrain, as is seen in controls.
Specimen Not shown: embryonic day 9.0; Fgf8tm1.3Mrt/Fgf8tm1.4Mrt, En1tm2(cre)Wrst/En1+ (more )
Note: Conditional mutant. 12-15 somites.
Structure Level Pattern Image Note
TS14: future midbrain Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory