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Gene Expression Data
Assay Details
Assay
Reference: J:69377 Wehrle-Haller B, et al., Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival. Dev Biol. 2001 Apr 15;232(2):471-83
Assay type: RNA in situ
MGI Accession ID: MGI:2449956
Gene symbol: Dct
Gene name: dopachrome tautomerase
Probe: TRP2 cDNA
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 2B, Nf1+: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest Present Regionally restricted 2B Staining in melanocyte precurors that are entering the lateral migration pathway.

Specimen 2C, Nf1-: embryonic day 11.5; Nf1tm1Fcr/Nf1tm1Fcr (more )
Structure Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest Present Regionally restricted 2C The number of melanocyte precursors at the original location is increased in this mutant.

Specimen 2D, Nf1+: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest Present Regionally restricted 2D Staining in melanocyte precurors that are entering the lateral migration pathway.

Specimen 2E, Nf1-: embryonic day 11.5; Nf1tm1Fcr/Nf1tm1Fcr (more )
Structure Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest Present Regionally restricted 2E The number of melanocyte precursors at the original location is increased in this mutant.

Specimen 3B, Nf1+: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: trunk mesenchyme derived from neural crest Present Regionally restricted 3B Expression in melanocyte precursors in the migration staging area.

Specimen 3E, NF1+: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: trunk mesenchyme derived from neural crest Present Regionally restricted 3E Expression in melanocyte precursors in the migration staging area.

Specimen 4B, MGF+, Nf1+: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: trunk mesenchyme Present Regionally restricted 4B Expression in melanocyte precursors on the lateral migration pathway, but not in the original migration staging area.

Specimen 4C, MGF+, Nf1-: embryonic day 12.5; Nf1tm1Fcr/Nf1tm1Fcr (more )
Structure Level Pattern Image Note
TS20: trunk mesenchyme Present Regionally restricted 4C Expression in melanocyte precursors on the lateral migration pathway, and in the original migration staging area.

Specimen 4D, MGF-, Nf1+: embryonic day 12.5; KitlSl/KitlSl (more )
Structure Level Pattern Image Note
TS20: trunk mesenchyme Absent 4D Melanocyte precursors are absent in this mutant.

Specimen 4E, MGF-, Nf1-: embryonic day 12.5; KitlSl/KitlSl, Nf1tm1Fcr/Nf1tm1Fcr (more )
Structure Level Pattern Image Note
TS20: trunk mesenchyme Present Regionally restricted 4E Melanocyte precursors are observed in the original location of the migration staging area, but not on the lateral migration pathway.

Specimen Not Shown, MGF-, Nf1-: embryonic day 12.5; KitlSl/KitlSl, Nf1tm1Fcr/Nf1tm1Fcr (more )
Structure Level Pattern Image Note
TS20: trunk mesenchyme Present Regionally restricted Melanocyte precurors are not present in the lateral migration pathway and remain in the migration staging area.

Specimen 4F, MGF+, Nf1+: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: trunk mesenchyme Present Regionally restricted 4F Expression in melanocyte precursors on the lateral migration pathway, but not in the original migration staging area.

Specimen 4G, MGF+, Nf1-: embryonic day 12.5; Nf1tm1Fcr/Nf1tm1Fcr (more )
Structure Level Pattern Image Note
TS20: trunk mesenchyme Present Regionally restricted 4G Expression in melanocyte precursors on the lateral migration pathway, and in the original migration staging area.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory