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Gene Expression Data
Assay Details
Assay
Reference: J:70745 Suda Y, et al., Emx2 directs the development of diencephalon in cooperation with Otx2. Development. 2001 Jul;128(13):2433-50
Assay type: RNA in situ
MGI Accession ID: MGI:2148275
Gene symbol: Gbx2
Gene name: gastrulation brain homeobox 2
Probe: Gbx2 cDNA10
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 2G: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted 2G Expression in dorsal thalamus.
TS19: telencephalon Present Regionally restricted 2G Expression in ganglionic eminence.
Specimen 2H: embryonic day 11.5; Emx2tm1Sia/Emx2tm1Sia, Otx2tm1Sia/Otx2+ (more )
Note: Emx2 and Otx2 heterozygotes were maintained by crosses with CBA mice. Single Emx2 and Otx2 heterozygotes (from F3 and F5 generations, respectively) were mated to generate double heterozygotes, which were subsequently mated to generate the double mutants.
Structure Level Pattern Image Note
TS19: diencephalon Absent 2H Absent in dorsal thalamus.
TS19: telencephalon Present Regionally restricted 2H Expression in ganglionic eminence.
Specimen 3O: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: future hindbrain Present Regionally restricted 3O Expression at isthmus.
TS15: future midbrain Present Regionally restricted 3O Expression at isthmus.
Specimen 3P: embryonic day 9.5; Emx2tm1Sia/Emx2tm1Sia, Otx2tm1Sia/Otx2+ (more )
Note: Emx2 and Otx2 heterozygotes were maintained by crosses with CBA mice. Single Emx2 and Otx2 heterozygotes (from F3 and F5 generations, respectively) were mated to generate double heterozygotes, which were subsequently mated to generate the double mutants.
Structure Level Pattern Image Note
TS15: future hindbrain Present Regionally restricted 3P Region of isthmic expression shifted anteriorly in the double mutant.
TS15: future midbrain Present Regionally restricted 3P Region of isthmic expression shifted anteriorly in the double mutant.
Specimen 5W: embryonic day 8.0 (more )
Note: 4-somite stage.
Structure Level Pattern Image Note
TS12: future hindbrain Present 5W Authors report expression in pre-otic and otic regions at 3-4 somite stages.
Specimen 5X: embryonic day 8.0; Emx2tm1Sia/Emx2tm1Sia, Otx2tm1Sia/Otx2+ (more )
Note: 4-somite stage. Emx2 and Otx2 heterozygotes were maintained by crosses with CBA mice. Single Emx2 (F3 gen.) and Otx2 (F5 gen.) heterozygotes were mated to generate double heterozygotes, which were subsequently mated to generate the double mutants.
Structure Level Pattern Image Note
TS12: future hindbrain Present Regionally restricted 5X Anterior limit of expression in the preotic region shifted rostrally.
Specimen 7K: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: thalamus Present Regionally restricted 7K Expression in dorsal thalamus.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory