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Gene Expression Data
Assay Details
Assay
Reference: J:25248 Conlon RA, et al., Notch1 is required for the coordinate segmentation of somites. Development. 1995 May;121(5):1533-45
Assay type: RNA in situ
MGI Accession ID: MGI:1276162
Gene symbol: Meox1
Gene name: mesenchyme homeobox 1
Results
Specimen 6A top: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS12: paraxial mesenchyme Present 6A top Expression in anterior presomitic mesoderm and somites.
TS12: somite Present 6A top Expression in anterior presomitic mesoderm and somites.
Specimen 6A bottom: embryonic day 8.5; Notch1tm1Con/Notch1tm1Con (more )
Note: Despite the normal pattern of expression of Mox-1, the mutant embryo mesoderm just anterior to the presomitic mesoderm is unsegmented.
Structure Level Pattern Image Note
TS12: paraxial mesenchyme Present 6A bottom Expression in anterior presomitic mesoderm and somites.
TS12: somite Present 6A bottom Expression in anterior presomitic mesoderm and somites.
Specimen 6I: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: trunk somite Present Graded 6I Mox-1 expression was strong in the posterior half of each somite.
Specimen 6J: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: trunk somite Present Graded 6J Mox-1 expression was strong in the posterior half of each somite.
Specimen 6K: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: trunk somite Present Graded 6K Mox-1 expression was strong in the posterior half of each somite.
Specimen 6L: embryonic day 9.5; Notch1tm1Con/Notch1tm1Con (more )
Note: Expression in the somites serves to highlight regions where somite segmentation has failed to occur and regions where somites are out of register across the midline.
Structure Level Pattern Image Note
TS15: trunk somite Present 6L The anterior/posterior difference seen in wild-type somites can be seen in some, but not all of the mutant somites.
Specimen 6M: embryonic day 9.5; Notch1tm1Con/Notch1tm1Con (more )
Note: Expression in the somites serves to highlight regions where somite segmentation has failed to occur and regions where somites are out of register across the midline.
Structure Level Pattern Image Note
TS15: trunk somite Present 6M The anterior/posterior difference seen in wild-type somites can be seen in some, but not all of the mutant somites.
Specimen 6N: embryonic day 9.5; Notch1tm1Con/Notch1tm1Con (more )
Note: Expression in the somites serves to highlight regions where somite segmentation has failed to occur and regions where somites are out of register across the midline.
Structure Level Pattern Image Note
TS15: trunk somite Present 6N The anterior/posterior difference seen in wild-type somites can be seen in some, but not all of the mutant somites.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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