Analysis Tools
immune system
microgliosis
(
J:379589
)
|
• Iba1 staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased microgliosis
|
|
• mice exhibit increased expression of IFN stimulated gene (ISG) mRNAs in brain of 6-week-old mice indicative of brain inflammation; ISG expression rapidly increases in young mice and is predominantly in deep brain areas indicating neuroinflammation
|
nervous system
astrocytosis
(
J:379589
)
|
• GFAP staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased astrocytosis
|
microgliosis
(
J:379589
)
|
• Iba1 staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased microgliosis
|
|
• mice exhibit increased expression of IFN stimulated gene (ISG) mRNAs in brain of 6-week-old mice indicative of brain inflammation; ISG expression rapidly increases in young mice and is predominantly in deep brain areas indicating neuroinflammation
|
hematopoietic system
microgliosis
(
J:379589
)
|
• Iba1 staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased microgliosis
|
cellular
astrocytosis
(
J:379589
)
|
• GFAP staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased astrocytosis
|
microgliosis
(
J:379589
)
|
• Iba1 staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased microgliosis
|
mortality/aging
| N |
• mice exhibit normal survival, development and body size
|
behavior/neurological
| N |
• mice do not exhibit neurologic phenotypes, with normal startle response and gait, and no muscle spasms, dystonia or seizures
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Aicardi-Goutieres syndrome | DOID:0050629 |
OMIM:225750 OMIM:610181 OMIM:610329 OMIM:610333 OMIM:612952 OMIM:615010 OMIM:615846 OMIM:PS225750 |
J:379589 | |
