Phenotypes Associated with This Genotype

Genotype
MGI:8315457

• Allelic Composition: Txndc15^em1Cya/Txndc15^em1Cya
• Genetic Background: C57BL/6JCya-Txndc15^em1Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:380495 )

• no pups are recovered at birth and 4 of 27 embryos obtained at E15.5 are stillborn

growth/size/body

omphalocele ( J:380495 )

• E15.5 embryos exhibit omphalocele

polycystic kidney ( J:380495 )

• E15.5 kidneys show phenotypes consistent with polycystic kidney disease

limbs/digits/tail

postaxial polydactyly ( J:380495 )

• 25.9% of E15.5 embryos exhibit postaxial polydactyly of the hind limbs with six digits

liver/biliary system

herniated liver ( J:380495 )

• E15.5 embryos exhibit hepatic herniation at the umbilicus

nervous system

encephalomeningocele ( J:380495 )

• 37.7% of E15.5 embryos exhibit occipital encephalocele

renal/urinary system

polycystic kidney ( J:380495 )

• E15.5 kidneys show phenotypes consistent with polycystic kidney disease

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Meckel syndrome		DOID:0050778	OMIM:PS249000	J:380495