Txndc15^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Txndc15^em1Cya
• Name: thioredoxin domain containing 15; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:8315406
• Synonyms: TXNDC15 c.560delA, Txndc15^mt
• Gene: Txndc15 Location: Chr13:55862463-55874040 bp, + strand Genetic Position: Chr13, 30.06 cM
• Alliance: Txndc15^em1Cya page
• IMPC: Txndc15 gene page

Mutation origin

• Strain of Origin: C57BL/6JCya
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting replicated a patient variant c.560delA (p.Asn187Ilefs4;NM_024715.4) in mice corresponding to c.512delA (p.Asn171Thrfs4) in the Txndc15-201 transcript (ENSMUST00000021959; NM_175150.3). (J:380495)

Disease models

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txndc15 Mutation: 18 strains or lines available

References

• Original: J:380495 Liu Y, et al., CRISPR-Cas9-Generated TXNDC15 c.560delA Homozygous Mouse Model Exhibits Meckel-Gruber Syndrome Phenotype. Genesis. 2026 Feb;64(1):e70040
• All: 1 reference(s)