Phenotypes Associated with This Genotype

Genotype
MGI:8297459

• Allelic Composition: Vsig10l^em1Guda/Vsig10l^em1Guda
• Genetic Background: C57BL/6J-Vsig10l^em1Guda

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

esophagogastric junction metaplasia ( J:379585 )

• mice fed a long-term diet supplemented with 0.2% deoxycholate develop Barretts esophagus-like mucinous metaplasia lesions at the squamous-columnar junction in the forestomach

abnormal forestomach morphology ( J:379585 )

• mice show a reduction in desmosomes in the suprabasal squamous cell layer of the forestomach

• forestomach squamous mucosa shows disrupted epithelial differentiation programs in Spatial Transcriptomics Profiling-based gene set enrichment analyses

neoplasm

increased incidence of induced tumors ( J:379585 )

• mice fed a long-term diet supplemented with 0.2% deoxycholate develop Barretts esophagus-like mucinous metaplasia lesions at the squamous-columnar junction in the forestomach

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Barrett's esophagus		DOID:9206	OMIM:614266	J:379585