Vsig10l^em1Guda
Endonuclease-mediated Allele Detail

Summary

• Symbol: Vsig10l^em1Guda
• Name: V-set and immunoglobulin domain containing 10 like; endonuclease-mediated mutation 1, Kishore Guda
• MGI ID: MGI:8288979
• Synonyms: Vsig10l KO
• Gene: Vsig10l Location: Chr7:43112575-43121443 bp, + strand Genetic Position: Chr7, 28.25 cM
• Alliance: Vsig10l^em1Guda page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 1-10 of the mouse Visg10l gene were deleted using CRISPR/cas9 methodologies (sgRNAs: upstream, 5'-ACCTGGGACAATGCAAGCTG-3'; downstream, 5'-AGGACTGGACCCTAAGAGTG-3'). (J:101977, J:379585)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vsig10l Mutation: 42 strains or lines available

References

• Original: J:379585 Ravillah D, et al., VSIG10L is a major determinant of esophageal homeostasis and inherited predisposition to Barrett's esophagus. Nat Commun. 2026 Jan 29
• All: 2 reference(s)