Phenotypes Associated with This Genotype

Genotype
MGI:8270469

• Allelic Composition: Unc93b1^em1Yuxz/Unc93b1^em1Yuxz
• Genetic Background: C57BL/6J-Unc93b1^em1Yuxz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

pancreas inflammation ( J:362436 )

growth/size/body

weight loss ( J:362436 )

• as mice age

enlarged spleen ( J:362436 )

• as mice age

spleen hyperplasia ( J:362436 )

• as mice age

hematopoietic system

extramedullary hematopoiesis ( J:362436 )

• in spleen

abnormal bone marrow hematopoietic cell morphology ( J:362436 )

• increased levels of CD45+ immune cells, macrophages, CD11b+/Gr-1+, CD16+/CD14- cells, regulatory T cells and activated T cells

abnormal spleen morphology ( J:362436 )

• inflammatory cell infiltration

enlarged spleen ( J:362436 )

• as mice age

spleen hyperplasia ( J:362436 )

• as mice age

abnormal splenic cell ratio ( J:362436 )

• decreased CD4 T cell to B cell ratio

increased splenocyte number ( J:362436 )

• increased number of B cells, regulatory and activated T cells, germinal center B cells, CD45+/CD19+/CD3-/CD95+/CXCR5+ cells and CD45+/CD4+/CD44+ cells

homeostasis/metabolism

increased circulating interferon-gamma level ( J:362436 )

increased circulating interleukin-10 level ( J:362436 )

increased circulating interleukin-12 level ( J:362436 )

increased circulating interleukin-6 level ( J:362436 )

immune system

pancreas inflammation ( J:362436 )

abnormal spleen morphology ( J:362436 )

• inflammatory cell infiltration

enlarged spleen ( J:362436 )

• as mice age

spleen hyperplasia ( J:362436 )

• as mice age

abnormal splenic cell ratio ( J:362436 )

• decreased CD4 T cell to B cell ratio

increased splenocyte number ( J:362436 )

• increased number of B cells, regulatory and activated T cells, germinal center B cells, CD45+/CD19+/CD3-/CD95+/CXCR5+ cells and CD45+/CD4+/CD44+ cells

increased circulating interferon-gamma level ( J:362436 )

increased circulating interleukin-10 level ( J:362436 )

increased circulating interleukin-12 level ( J:362436 )

increased circulating interleukin-6 level ( J:362436 )

increased anti-double stranded DNA antibody level ( J:362436 )

• in serum

• normal total IgG antibody level

lung inflammation ( J:362436 )

renal/urinary system

expanded mesangial matrix ( J:362436 )

small kidney ( J:362436 )

respiratory system

lung inflammation ( J:362436 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:362436