Analysis Tools
behavior/neurological
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• in the tail suspension test, mice exhibit a hypermobile phenotype, spending more time struggling than controls, struggling for 307 sec compared to 149.7 sec in wild-type mice
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• in the forced swim test, mice exhibit hypermobility during 20 to 210 sec of vigorous swimming before diving erratically beneath the waters surface in a disorganized and maladaptive manner and had to be rescued from drowning once they start diving; only 12.5% of mice can swim 6 min without rescue
• 54% of mice treated with the antidepressant fluoxetine for 9 weeks achieve a normal 6 minute forced swim test and mice treated with the antidepressant imipramine show a less robust but significant improvement in swimming
• however, mice behave similar to wild-type mice in tests for motor coordination, balance, activity, and locomotion
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• in the light-dark box test, mice enter the bright zone less frequently and spend less time there
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• in the elevated plus maze, mice exhibit 57% less open arm exploration compared to wild-type mice
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nervous system
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• medial habenula neurons have a slightly depolarized resting membrane potential compared to controls
• no differences in other passive membrane properties or excitatory postsynaptic potentials are seen
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• average tonic medial habenula firing is higher than in wild-type brain, indicating hyerpactivity in a brain region linked to mood regulation
• mice treated with the antidepressant fluoxetine for 9 weeks show decreased firing rate of medial habenula neurons to an intermediate level between untreated and control values
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| depressive disorder | DOID:1596 | J:373573 | ||
