Gpr156^{tm3.1(GPR156*E533D)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Gpr156^{tm3.1(GPR156*E533D)Vlcg}
• Name: G protein-coupled receptor 156; targeted mutation 3.1, Velocigene
• MGI ID: MGI:8255455
• Synonyms: Gpr156^E533D
• Gene: Gpr156 Location: Chr16:37736858-37827892 bp, + strand Genetic Position: Chr16, 26.54 cM
• Alliance: Gpr156^{tm3.1(GPR156*E533D)Vlcg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:373573
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Gpr156^{tm3.1(GPR156*E533D)Vlcg} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GPR156 (165829)

  Gpr156

  (MGI:2653880)

  Contains p.E533D variant

• Mutation details: The mouse ATG to stop genomic sequence was replaced with human GPR156 (ATG to 100 bp beyond the end of the 3' UTR region) containing a G to T change at position 1599 (c.1599G>T) that results in a glutamate to aspartate substitution at amino acid 533 (p.E533D) in coding exon 9. A self-deleting puromycin resistance cassette was placed just after the human sequence, at the 3' end. The puromycin resistance cassette was removed. The p.E533D missense variant was identified in an Old Order Mennonite family cohort associated with a risk of major depressive disorder. (J:373573)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr156 Mutation: 41 strains or lines available

References

• Original: J:373573 Miller BR, et al., A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice. Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2404754122
• All: 1 reference(s)