Phenotypes Associated with This Genotype

Genotype
MGI:8254644

• Allelic Composition: Gt(ROSA)26Sor^{em1(CAG-SNCA,-ZsGreen)Yfa}/Gt(ROSA)26Sor⁺; Tg(Nes-cre)1Kln/0
• Genetic Background: B6.Cg-Gt(ROSA)26Sor^{em1(CAG-SNCA,-ZsGreen)Yfa} Tg(Nes-cre)1Kln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:373287 )

• mice at 12 months of age show reduced motor coordination on the rotarod, with shorter times before falling

decreased locomotor activity ( J:373287 )

• 12-month-old mice travel shorter distances in the open field test

bradykinesia ( J:373287 )

• in the pole test, 12-month-old mice take longer to turn and complete the task, indicating motor deficits and bradykinesia

nervous system

abnormal axon guidance ( J:373287 )

• axon guidance-related genes in the midbrain and striatum are dysregulated at 3 and 8 months of age

loss of dopaminergic neurons ( J:373287 )

• no difference in TH+ neuron counts at 3 and 8 months of age, however by 12 months, months show a reduction in TH+ neurons, indicating progressive loss of dopaminergic neurons

abnormal dendrite morphology ( J:373287 )

• dendritic atrophy in the midbrain and striatum is seen in 8-month-old mice

decreased dendritic spine density ( J:373287 )

• mice show deceased dendritic spine density in the midbrain and striatum

decreased dendritic spine length ( J:373287 )

• mice show deceased dendritic length in the midbrain and striatum

decreased dendritic spine number ( J:373287 )

• mice show deceased dendritic branch number in the midbrain and striatum

abnormal synapse morphology ( J:373287 )

• reduction in synaptic protein levels in the midbrain at 3 and 8 months and in the striatum at 8 months, indicating early synaptic dysfunction

neurodegeneration ( J:373287 )

• progressive loss of dopaminergic neurons

cellular

abnormal axon guidance ( J:373287 )

• axon guidance-related genes in the midbrain and striatum are dysregulated at 3 and 8 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:373287