Phenotypes Associated with This Genotype

Genotype
MGI:8250466

• Allelic Composition: Capza2^em1Yoch/Capza2⁺
• Genetic Background: C57BL/6-Capza2^em1Yoch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal object recognition memory ( J:370017 )

• in the novel object recognition test, mice show an impaired ability to distinguish between novel and familiar objects, with a lower recognition index, indicating deficits in recognition memory

impaired spatial learning ( J:370017 )

• in the Morris water maze, mice show longer escape latencies from the 4th day of training onwards, indicating impaired spatial learning

abnormal long-term spatial reference memory ( J:370017 )

• probe tests show a lack of quadrant preference and reduced platform crossings indicating deficits in hippocampus-dependent spatial memory

impaired spatial working memory ( J:370017 )

• mice show lower rates of spontaneous alternation in the Y-maze, but no difference in the total number of arms traversed, indicating impaired spatial working memory

increased anxiety-related response ( J:370017 )

• mice spend increased time in the outer zone of the open field test, indicating heightened anxiety

• in the elevated plus maze, mice enter the open arm for a reduced time, with a corresponding reduction in the distance traveled in the open arm and a higher distance traveled in the closed arm

decreased social novelty preference ( J:370017 )

• in the three-chambered social interaction test, mice do not differentiate between familiar and novel mice during the social novelty phase, indicating an impairment in novelty recognition

impaired coordination ( J:370017 )

• mice show reduced latency to fall off the rotarod, indicating impaired motor balance

hyperactivity ( J:370017 )

• in the open field test, mice exhibit hyperactivity

decreased social investigation ( J:370017 )

• in the three-chambered social interaction test, mice do not show a preference for the chamber containing another mouse, indicating an impairment in social interaction

nervous system

abnormal neuron differentiation ( J:370017 )

• marker analysis indicates decreased neurogenesis in the hippocampus

abnormal brain morphology ( J:370017 )

• mice show an increase in brain mass

abnormal hippocampus neuron morphology ( J:370017 )

• hippocampus shows reduced neuronal counts

decreased dendritic spine density ( J:370017 )

• prefrontal cortex shows a decrease in dendritic spine density

increased dendritic spine density ( J:370017 )

• hippocampus shows maintained dendritic complexity but increased spine density with a tendency towards immature spine morphologies

decreased dendritic spine number ( J:370017 )

• prefrontal cortex regions show diminished dendritic branching

abnormal synapse morphology ( J:370017 )

• marker analysis indicates synaptic disruption in the hippocampus

cellular

abnormal neuron differentiation ( J:370017 )

• marker analysis indicates decreased neurogenesis in the hippocampus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
intellectual disability		DOID:1059		J:370017