Phenotypes Associated with This Genotype

Genotype
MGI:8248856

• Allelic Composition: Capza2^em1Cya/Capza2⁺
• Genetic Background: C57BL/6N-Capza2^em1Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal object recognition memory ( J:370017 )

• in the novel object recognition test, mice show an impaired ability to distinguish between novel and familiar objects, with a lower recognition index, indicating deficits in recognition memory

impaired spatial learning ( J:370017 )

• in the Morris water maze, mice take longer to locate the platform, especially on the 5th day of training, indicating spatial learning difficulties

abnormal long-term spatial reference memory ( J:370017 )

• in a subsequent probe test, mice show longer latencies to reach the target location for the first time and fewer passes over the target, and spend less time in the target quadrant

impaired spatial working memory ( J:370017 )

• in the Y-maze, mice show decreased spontaneous alternations without affecting arm entry counts, indicating a defect in spatial working memory

increased anxiety-related response ( J:370017 )

• in the open field test, mice show an increase in outer zone distance traveled, suggesting increased anxiety-like behavior

• in the elevated-plus maze, mice tend to spend less time in the open arms than wild-type mice and cover a relatively shorter distance in the open arms while traveling a longer distance of the closed arms of the elevated-plus maze

decreased social novelty preference ( J:370017 )

• in the three-chambered social interaction test, mice do not differentiate between familiar and novel mice during the social novelty phase, indicating an impairment in novelty recognition

impaired coordination ( J:370017 )

• mice show shorter latencies to fall from the rotarod, indicating compromised motor balance

increased locomotor activity ( J:370017 )

• in the open field test, mice show an increase in both total and outer zone distance traveled, suggesting increased locomotor activity

decreased social investigation ( J:370017 )

• in the three-chambered social interaction test, mice do not show a preference for the chamber containing another mouse, indicating an impairment in social interaction

nervous system

abnormal neuron morphology ( J:370017 )

• breaks in dendrites and their branches are seen across both the hippocampus and prefrontal cortex, indicating neuronal damage

abnormal neuron differentiation ( J:370017 )

• marker analysis indicates decreased neurogenesis in the hippocampal dentate gyrus

abnormal dendritic spine morphology ( J:370017 )

• dendritic spines in the hippocampal dentate gyrus neurons show more elongated, thin, and curvilinear structures suggesting immature spine development

decreased dendritic spine density ( J:370017 )

• prefrontal cortex shows a decrease in dendritic spine density and the presence of fewer mature spines

increased dendritic spine density ( J:370017 )

• increase in dendritic spine density in the hippocampal dentate gyrus neurons

• however, dendritic complexity in the hippocampal dentate gyrus neurons is normal

increased dendritic spine length ( J:370017 )

• dendritic spines in the hippocampal dentate gyrus neurons show more elongated structures

decreased dendritic spine number ( J:370017 )

• prefrontal cortex shows a reduction in the number of neuronal dendritic branches at varying distances from the soma

increased dendritic spine number ( J:370017 )

• increase number of overall dendritic spines in the hippocampal dentate gyrus neurons

abnormal dentate gyrus neuron dendrite morphology ( J:370017 )

• neurons in the hippocampal dentate gyrus are characterized by disrupted, fragmented, and disorganized dendritic structures

cellular

abnormal neuron differentiation ( J:370017 )

• marker analysis indicates decreased neurogenesis in the hippocampal dentate gyrus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
intellectual disability		DOID:1059		J:370017