Phenotypes Associated with This Genotype

Genotype
MGI:8240384

• Allelic Composition: Cry1^em1Lijd/Cry1^em1Lijd
• Genetic Background: C57BL/6-Cry1^em1Lijd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired long-term object recognition memory ( J:371309 )

• in the novel object recognition test the discrimination index for the novel object is still lower at 24 hours after training when assays are performed at ZT14-16 but not at ZT02-04

impaired spatial working memory ( J:371309 )

• in the Y-maze, mice show lower alternation when done at Zt14-16, but not at ZT02-04

• treatment with SCH23390 during ZT14-16 rescues the impaired memory

impaired learning ( J:371309 )

• in the novel object recognition test, mice are not able to discriminate the novel object as well as wild-type mice at 1 hour after training regardless of whether the assays were performed at ZT14-16 or ZT02-04

• treatment with SCH23390 during ZT14-16 rescues the impaired learning

decreased depression-related behavior ( J:371309 )

• in the tail suspension test and forced swim test, mice are less despairing as shown my reduced immobile time during ZT14-16 but no differences at ZT02-04 indicating reduced depression-like behaviors in a circadian time-dependent manner

• treatment with SCH23390 during ZT14-16 normalizes the reduced immobility time in the tail suspension test but has no effect in the forced swim test

decreased anxiety-related response ( J:371309 )

• during both ZT02-04 and ZT14-16 periods, mice show a higher percentage of distance traveled in the center zone of the open field test, indicating a reduced anxiety-like behavior

• in the elevated plus maze performed during ZT14-16, mice spend more time in the open arms and the latency to the open arms is shorter indicating reduced anxiety-like behavior in a circadian time-dependent manner

• treatment with SCH23390 during ZT14-16 normalizes the reduced anxiety-like behaviors

abnormal response to novel object ( J:371309 )

• in the novel object recognition test, mice are not able to discriminate the novel object as well as wild-type mice at 1 hour after training regardless of whether the assays were performed at ZT14-16 or ZT02-04 and the discrimination index is still lower at 24 hours after training when assays are performed at ZT14-16 but not at ZT02-04

abnormal impulsive behavior control ( J:371309 )

• mice exhibit impulsivity, with mice spending more time and traveling longer distances in the lit box in light-dark transition tests

• in the elevated plus maze performed during ZT14-16, mice spend more time in the open arms and the latency to the open arms is shorter indicating reduced anxiety-like behavior in a circadian time-dependent manner

hyperactivity ( J:371309 )

• during both zeitgeber time (ZT)02-04 (ZT is measured in hours after the light has been turned on in a 12-hour light/dark cycle) and ZT14-16 periods, mice travel longer distances and cross more zones that wild-type mice in the open field test indicating hyperactivity

• in the Y-maze, the total number of arm entries are higher

• mice travel longer distance in the elevated plus maze

• treatment with the DRD1 antagonist SCH23390 during ZT14-16 rescues the hyperactivity

• however, mice show no difference in the free-running periods under constant darkness

nervous system

abnormal action potential ( J:371309 )

• dopamine D1 receptor-expressing medium spiny neurons (DRD1+ MSNs) exhibit higher action potential firing frequency and depolarizing resting membrane potential than wild-type controls

• however, no difference is seen in non-dopamine D1 receptor-expressing medium spiny neurons (DRD1- MSNs)

• DRD1+ MSNs show a decrease of rheobase indicating hyperexcitability, however this hyperactivity is not attributed to the change of cell input resistance

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
attention deficit hyperactivity disorder		DOID:1094	OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312	J:371309